Taking a science-based look at an emerging area of medicine, Adaptive Biology and Medicine: New Frontiers, Volume 3 discusses the biology of adaptation at the molecular, cellular, and system levels in response to a variety of stressful conditions. Leading international experts present a total of 37 chapters that cover a common continuum of adaptations. For easy reading, the information has been grouped under the sub-headings: Cardiovasular Adaptation, Adaptations to Changes in Altitude and Microgravity, and Environmental Stresses. Examples of cross adaptations are included where repeated exposure to one stimulus may have applications in the treatment and prophylaxis of different diseases.
Understanding disease and the mechanisms involved can help us fight disease. When you look at illness through the lens of adaptive biology you can sometimes see medical problems in a new and thought-provoking light. Offering promise for therapeutic strategies in both experimental and clinical pathology, Adaptive Biology and Medicine: New Frontiers explores a new way of thinking about physiological adaptations and their link to disease development.
CARDIOVASCULAR ADAPTATIONS
Prevention of Hemorrhagic Shock-Induced Disturbabances with Adaptation to Stress or Hypoxia, Y.V. Arkhipenko, A.G. Zhukova, N.V. Kizichenko, and T.G. Sazontova
Immediate Cardiac Preconditioning with Mild Oxidant Sresses, F.R. Boucher, M.-C. Toufektsian, S. Tanguy, S. Morel, and J.G. de Leiris
Omega-3 Fatty Acids and Resistance of the Myocardium to Ischemia-Induced Ventricular Arrhythmias, M. de Lorgeril, P. Salen, and F. Paillard
Mechanisms of Action of Dietary n-3 Polyunsaturated Fatty Acid During Myocardial Stunning: Reference to Mitochondrial Energy Metabolism, E. Sentex and L. Demaison
Erythropoietin and Vascular Endothelial Growth Factor in Humans Under Normobaric and Hypobaric-Hypoxic Conditions, H.C. Gunga, K. Kirsch, L. Rocker, C. Behn, E. Koralewski, E.H. Davila, M.I. Estrada, B. Johannes, P. Wittels, and W. Jelkman
Myocardial Cell Engineering, S. Tomita, T.M. Yau, D.A.G. Mickle, R.D. Weisel, and R.-K. Li
Saturated, n-3 and n-6 Polyunsaturated Fatty Acids and Cardiac Arrhythmias, D. Moreau
Cell-Cell Interactions in Cardiomyopathy, S. Onishi, N. Kawaguchi, N. Tani, E. Oiki, and N. Matsuura
Mitochondrial Membrane Alterations by Aging and Diet: Impact on Recovery of Myocardial Function after Stress, S. Pepe, F.L. Rosenfeldt, E.G. Lakatta, and S.L. Sollott
Protective Effects of Cytoplasmic Factors on the Membrane System of Ca2+ Transport of Myocardial and Skeletal Muscle Sarcoplasmic Reticulum, T.G. Sazontova, A.A. Matskevich, and Y.V. Arkhipenko
Oxidative Stress and Myocyte Cell Death in the Failing Human Heart, D. Kumar, J. Narula, A. Kaushal, and P.K. Singal
Effects of Diabetes on Cation and Contraction in the Isolated Rat Heart, F.C. Howarth, M.A. Qureshi, W. Winlow, J. Singh, and N.K. Bracken
Adaptation of the Isolated Rat Heart to Osmotic Shock, J. Singh, F.C. Howarth, N. Bracken, A.M. Qureshi, and B.I. Hustler
ADAPTATIONS TO CHANGES IN ALTITUDE AND MICROGRAVITY
Nitrogen at Raised Pressure Produces Narcosis Through an Activation of the GABAA, but not the GABAB, Receptor, J.H. Abraini and H.N. David
A Potential Adaptation Strategy to Enable the Toothed Whales to Reach Extreme Depths, S. Daniels and M.L. Dunstan
Microgravity-Induced Orthostatic Intolerance: An Arterial Microvascular Mechanism, M.D. Delp
Dimensions of Brachiosaurus brancai, Dicraeosaurus hansemanni, and Diplodocus carnegii and their Implecations for Gravitational Physiology, H.-C. Gunga, K. Kirsch, J. Rittweger, A. Clarke, J. Albertz, A. Wiedemann, A. Wehr, W.-D. Heinrich, and H.-P. Schultze
Microgravity-Induced Vascular Hyporesponsiveness: Nitric Oxide Dependent-Mechanisms Identified in a Ground-Based Simulation Model, R.E. Purdy
Structural and Functional Adaptations of Vessels to Microgravity, L.-F. Zhang and L.-N. Zhang
Blood Volume Changes During Altitude Acclimitization: Implications for Aerobic Performance, A.J. Young and M.N. Sawka
Gravitational Environment and Bone Tissue: Lessons from Space Studies, E. Zérath
ENVIRONMENTAL STRESSES
Heatstroke, Susceptibility to Heat and Stress, L. Bourdon, F. Canini, and A. Buguet
NO a Cornerstone in Sleeping Sickness: Voltammetric Assessment in Animal and Man, A. Buguet, S. Banzet, B. Bouteille, P. Vincendeau, P. Tapie, F. Doua, P. Bogui, and R. Cespuglio
Brain Nitric Oxide in Heatstroke, F. Canini, L. Bourdon, R. Cespuglio, and A. Baguet
Brain Excitotoxic Networks in Heatstroke, F. Canini and L. Bourdon
Hypoxitherapy Today and in the Future, A.Y. Chizhov and A.A. Bludov
CNS Regulation of BAT Function and Arousal from Hibernation in Hamsters, M. Hashimoto, A. Kuroshima, and M. Shibata
Human Colorectal Carcinoma is a Direct Target Tissue for Growth Hormone: Evidence of Receptor Adaptation, D.T. Lincoln, L. Temmim, M.A. Al-Jarahallah, H.T. Abul, F. Clarke, and M.J. Waters
Cellular Mechanism Responsible for Beneficial Effects of Hypoxic Therapy, L.D. Lukyanova
Oxygen-Dependent Processes in Tissues Under Adaptation to Intermittent Hypoxia and Their Clinical Significance, I. Mankovskaya, Z. Serebrovskaya, R.J. Swanson, V. Nosar, T. Serebrovskaya, and K. Lyabakh
Role of Nitric Oxide in Protective Effects of Adaptation, E.B. Manukhina and I.Y. Malyshev
An Ultrastructural Observation of Lungs Treated by the Hypoxic Therapy: An Assessment of its Therapeutic Efficacy as one of the Impulse Therapy, K. Okuyama, J. Jiang, and K. Aihara
Comparison between Neurochemical and Behavioural Effects of High Pressure and Inert Narcotic Gases: Is There any Adaptive Mechanism? J.J Risso, B. Lego, A. Saget, E. Carre, A. Moulins, and O. Darbin
Nervous System in Hyperbaric Conditions, J.-C. Rostain and R. Balon
Effect of Ageing on Morphology and Protein Secretion and Synthesis in the Isolated Rat Lacrimal Gland, E. Adeghate, J. Singh, and C. Draper
Mechanisms of Fatigue During Exercise-Heat Stress, A. Strachan and R. Maughan
Cellular Mechanisms of Right Ventricular Hypertrophy in Rats Adapted to Low Pressure Hypoxia, M. Moravec, Z. Turek, and J. Moravec