Table of Contents

INTERALLELIC AND INTERGENIC INTERACTIONS
Interallelic Interactions
Intergenic Inheritance
Totipotency
Pleiotropy
Homeostasis

NON-MENDELIAN INHERITANCE
Extranuclear Inheritance
Yeast Mitochondrial Genome
Universality of Genetic Code
Mitochondrial Genes and Diseases
Maternal Effects
Nucleocytoplasmic Interactions
Extrachromosomal Inheritance
Hybrid Dysgenesis

GENETICS OF SYMBIOSIS
Commensalism, Mutualism, and Parasitism
Kingdoms of Living Organisms
Endosymbionts and Ectosymbionts
Viruses in Bacteria
Agrobacterium and Crown Gall Disease
Nitrogen-Fixing Symbiosis
Host-Parasite Interactions

RECOMBINATION IN DROSOPHILA MALES
Complete Linkage in Drosophila Males
Fold-Back Elements of Drosophila

GENE AMPLIFICATIONS
Amplification During Differentiation and Development
Amplification by Selection
Amplification and Tumorigenesis
Amplification of Transferred Genes
Arrangement of Amplified Chromosomal DNA
Random vs Directed Gene Amplification

GENETIC CONTROL OF FUNCTION
Relationship Between Gene and Enzyme
Genetic Control of Biochemical Reactions
Relationship Between Genotype and Phenotype
One Gene-One Enzyme Hypothesis
One Gene-One Polypeptide Hypothesis
One Cistron-One Polypeptide
One Gene-One Primary Cellular Function Hypothesis
Pseudogenes

GENE EXPRESSION AND ITS ANALYSIS
Central Dogma and Its Reversal
Gene Expression
RNAs: Their Processing and Functions
Self-Splicing or rRNA in Tetrahymena
Genetic Code
Transcriptional Elements
Synergistic Gene Expression
Environmental Effects and Gene Expression
Hormones and Gene Expression
Penetrance and Expressivity
Phenocopies
Alternative RNA Splicing
Gene Silencing

GENETIC CONTROL OF PROTEIN SYNTHESIS
Translation in Prokaryotes
Translation in Eukaryotes
Fate of Completed Proteins
Protein Targetting
Protein Secretion
Molecular Chaperone

GENE REGULATION IN PROKARYOTES
Terminology of Gene Regulation
Mechanism of Gene Regulation in Prokaryotes
Antisense RNA in Prokaryotic Gene Regulation
Prokaryotic Gene Regulation by DNA Rearrangements
Alternative Sigma Factors

GENE REGULATION IN EUKARYOTES AND MODELS OF GENE
Is Operon Concept Applicable to Eukaryotes?
Short-Term Versus Long-Term Regulation
Mechanisms of Gene Regulation in Eukaryotes
Gene Regulation by Hormonal Action
DNA Methylation and Gene Regulation
Gene Control Levels in Eukaryotic Cells
Models of Gene Regulation
Transcriptional Initiation in Mammalian Genes
CAT-and TATA-binding Transcription Factors
Antisense RNA Strategies in Eukaryotes
Molecular Zippers in Gene Regulation
Regulation of Gene Expression by Small Molecules
Histones as Repressors of Gene Expression
Eukaryotic Gene Regulation Through DNA Rearrangements
Artificial Gene Repressors
Specificity in Eukayotic Gene Transcription

GENETIC ENGINEERING
Restriction Endonucleases
Gene/DNA Cloning
Gene Transfer Methods
Chromosome Walking/Jumping Libraries
Minisatellites and Microsatellites
Polymerase Chain Reaction
Transposon-Mediated Gene Transfer
High Density Molecular Maps
DNA Fingerprinting
LOD Score
Applications of Genetic Engineering
Hazards of Genetic Engineering
Gene Targetting
Transgenic Plants
Transgenic Animals
Expression and Stability of Genetically Engineered Genes
Genetically-Modified Food
Gene Chip Technology

GENE PATENTING
Requirements of Patentability
What Can Be Got Patented?
Patenting - An International Activity
Requirements for Depositing a Culture
Patenting for Life Forms
Selling the Sequences
Property Rights
Controversies on Genetic Manipulations
Patenting and Agricultural Industry
Economic Grains
Impact of Patenting on Less Developed Nations
Proposed Amendments on Patents Act, 1970

MAPPING QUANTITATIVE TRAIT LOCI
Reasons for Locating QTLs
Linkage of a Quantitative Trait to a Major Gene
Principle of QTL Mapping
Advanced Backcross of QTL Method
Mapping QTLs with MAPMAKER
Usefulness of QTL Mapping
Limitations of QTL Analysis
Fine Mapping of QTL
QTL Meta-Analysis

IMMUNOGENETICS
Immunoglobulins
Human Leukocyte Antigens
Vaccines

GENETIC DISORDERS IN MAN
Genetic Basis of Disorders
Disorders Due to Mutations
Diagnosis and Carrier Detection
Somatic Cell Hybridization
Treatment for Inherited Diseases
Gene Therapy

ONCOGENES AND ANTIONCOGENES
Retroviruses Contain Oncogenes
Proto-Oncogenes
src Oncogene
Origin of Oncogenes
Indentification of an Oncogene
Fine Structure of an Oncogene
Activation of Proto-Oncogenes
A Model of Carcinogenesis
Evidences Supporting Pall's Model
Antioncogenes

SEX DETERMINATION, DOSAGE COMPENSATION AND SEX DIFFERENTIATION
Sex-Determination
Noncoding DNA as Hypothesis for Sex-Determination
Dosage Compensation
Sex Differentiation
Events in Sex Determination
Human Sex Anomalies

EPIGENETICS AND MORPHOGENETICS
Epegenetic Patterns
Mutations and Epimutations
Cellular Transformation
Chromosome Imprinting
Epigenetic Defects and Ageing
DNA Methylation in Plants
Molecular Morphogenesis
Common Coding Motifs
Homeotic Genes in Flower Development

ORIGIN OF PROKARYOTIC AND EUKARYOTIC CELL
Organic Evolution
What is Life?
Theories of Origin of Life
Mechanism of Origin of Life on Earth
Evolution of Eukaryotes
Theories on the Origin of Eukaryote Cells
Evolution of Sexual Reproduction

PROCESS OF EVOLUTION
Lamark's Theory of Evolutio
Theory of Natural Selection
Mutation Theory of Evolution
Modern Synthetic Theory of Evolution

MOLECULAR EVOLUTION
Biological Species Concept
Genetics of Reproduction Isolation
Genetic Distance
An Era of Molecular Biology
Evolutionarily Important Genes
Molecular Evolutionary Clock
Genome Organization and Evolution
Selfish DNA
Molecular Drive
Proteome
Cryptic Variation
Establishment of New Patterns of Gene Control
Epochs of Molecular Evolution

GENOMICS
Assigning Function to a Gene
Tools to Study Functional Genomics
Potential Applications of Functional Genomics