Anticancer Agents from Natural Products
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Summary
Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screening techniques and molecular targets proliferate, natural products are once again taking a central part of modern pharmaceutical research. Anticancer Agents from Natural Products analyzes current clinically-used anticancer agents that are natural products or clearly derived from natural product leads.
This multi-authored volume provides a historical, biochemical, and chemical rationale to the search for plant, marine, or microbial sources that may provide future templates for drug lead optimization and synthetic drug design. Grouped by source organism, each chapter includes the history of the drug and a discussion of its mechanism in action, medicinal chemistry, and biochemistry. The authors characterize each compound by its structure, genetics, molecular biology, synthesis, and possible derivatives. They also discuss \approaches to drug discovery and development, including the use of combinatorial biosynthetic techniques, testing methods, and ways to obtain economically viable amounts of the drug. The final chapter covers drug candidates that are in preclinical or clinical development and may be used in the future.
Edited by leading scientists who have contributed enormously to natural product development and potential anticancer natural products, Anticancer Agents from Natural Products is a convenient summary of the current status of research and development of some of the most effective anticancer agents available today. It is an ideal foundation for scientists engaged in developing new and improved drugs based on natural sources.
Table of Contents
Introduction; G.M. Cragg, David G. I. Kingston, and D.J. Newman
Camptothecin and its Analogs; N.J. Rahier, C.J. Thomas, and S.M. Hecht
The Discovery and Development of the Combretastatins; K.G. Pinney, C. Jelinek, K. Edvardsen, D.J. Chaplin, and G.R. Pettit
Homoharringtonine and Related Compounds; H. Itokawa, X. Wang, and K.-H. Lee
Podophyllotoxins and Analogs; K.-H. Lee and Z. Xiao
Taxol and Its Analogs; David G. I. Kingston
The Vinca Alkaloids; F. Guéritte and J. Fahy
The Bryostatins; D.J. Newman
The Isolation, Characterization, and Development of a Novel Class of Potent Antimitotic Macrocyclic Depsipeptides: The Cryptophycins; R.S. Al-Awar and C. Shih
Chemistry and Biology of the Discodermolides, Potent Mitotic Spindle Poisons; S.P. Gunasekera and A.E. Wright
The Dolastatins: Novel Antitumor Agents from Dolabella auricularia; E. Flahive and J. Srirangam
Ecteinascidin 743 (ET-743; Yondelis™), Aplidine, and Kahalalide F; R. Henriquez, G. Faircloth, and C. Cuevas
Discovery of E7389, a Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B; M.J. Yu, Y. Kishi, and B.A. Littlefield
HTI-286, A Synthetic Analog of the Antimitotic Natural Product Hemiasterlin; R.J. Andersen and M. Roberge
The Actinomycins; A.B. Mauger and H. Lackner
Anthracyclines; F.M. Arcamone
Ansamitocins (Maytansinoids); T.-W. Yu and H.G. Floss
Benzoquinone Ansamycins; K.M. Snader
Bleomycin Group of Antitumor Agents; S.M. Hecht
Biochemical and Biological Evaluation of (+)-CC-1065 Analogs and Conjugates with Polyamides; R. Kumar and J.W. Lown
Epothilone, a Myxobacterial Metabolite with Promising Antitumor Activity; G. Höfle and H. Reichenbach
Enediynes; P.R. Hamann, J. Upeslacis, and D.B. Borders
The Mitomycins; W.A. Remers
Staurosporines and Structurally Related Indolocarbazoles as Antitumor Agents; M. Prudhomme
Combinatorial Biosynthesis of Anticancer Natural Products; M.G. Thomas, K.A. Bixby, and B. Shen
Developments and Future Trends in Anticancer Natural Products Drug Discovery; D.J. Newman and G.M. Cragg
Index
Editorial Reviews
"The book brings home to us not only the amazing chemical complexity of the natural world but also the vast reservoir of potential new healing agents that yet remain to be tapped. This impressive work, which maintains a uniformly high standard throughout, will be of major benefit to a wide readership… .It seems likely that it will remain the definitive work in its genre for many years to come."
-Chemistry World Vol. 3, No. 3, March 2006
"Edited by leading scientists who have contributed enormously to natural product development and potential anticancer natural products, Anticancer Agents from Natural Products is a convenient summary of the current status of research and development of some of the most effective anticancer agents available today. It is an ideal foundation for scientist engaged in developing new and improved drugs based on natural sources."
– In Memoriile Sectiilor Stintifice, 2006
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