Handbook on Clostridia
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Summary
Clostridia is one of the largest bacterial genera with an enormous potential for biotechnical and medical applications. Despite growing scientific, medical, and industrial interest, information on basic methods, biochemical fundamentals, clinical practice, industrial applications, and novel developments remains scattered in a variety of research articles, reviews, and book chapters.
Responding to this gap in the literature, Handbook on Clostridia combines all of these topics into a single volume. The editor takes a global approach by presenting information on both Clostridia of biotechnological importance and Clostridia of medical importance. Experts in the field summarize methods, physiology, medical significance, regulation, ecosystems, genomics, and current and potential applications.
Providing a comprehensive resource on the complete field of Clostridium, this book also serves as a compilation of critical reviews on the advantages of using Clostridia for new medical and biotechnological applications. It is a valuable reference for every specialist, researcher, and student involved in this promising field.
Table of Contents
I. Methods
Species and strain identification methods; Jones and Keis
Quantitative proteome analysis of clostridia; Schaffer, Thormann, Hujer, and Dürre
Gene cloning in clostridia; Davis, Carter, Young, and Minton
Gene analysis of clostridia; Tummala, Tomas, and Papoutsakis
Anoxic testing and purification of enzymes; Thorsten Selmer
II. Metabolic Pathways and Transport Systems
Degradation of polymers: cellulose, xylan, pectin, starch; Leschine
Genetic organisation and regulation of hexose and pentose utilization in the clostridia; Reid
Carbohydrate uptake by the phosphotransferase system and other mechanisms; Mitchell and Tangney
Special clostridial enzymes and fermentation pathways; Buckel
Degradation of heterocyclic compounds; Andreesen
Nitrogen assimilation in the clostridia; Reid and Stutz
Nitrogen fixation; Chen
Clostridial potassium transport systems; Treuner-Lange and Dürre
Transport of phosphate; Fischer and Bahl
III. Cellular Components and Medical Aspects
Membranes lipids of clostridia; Goldfine and Johnston
Adhesins; Mastrantonio and Collignon
Clostridial toxins versus other bacterial toxins; Popoff and Stiles
Clostridial enterotoxins; McClane
Clostridial cytotoxins; Barth and Aktories
Membrane active toxins; Titball and Tweten
Clostridial neurotoxins; Johnson
Clostridial diseases of domestic animals; Songer
IV. Regulatory Mechanisms
Two-component signal transduction systems in the clostridia; Cheung, McGowan, and Rood
Comparative genomic analysis of signal transduction proteins in clostridia; Dob, Gröger, Knauber, Whitworth, and Treuner-Lange
Regulation of catabolic gene systems; Tangney and Mitchell
RNA polymerase and alternative s factors; Sonenshein, Haraldsen, and Dupuy
Transposable genetic elements of the clostridia; Lyras and Rood
V. Complex Regulatory Networks
Sporulation (morphology) of the clostridia; Labbé
Sporulation in clostridia (genetics); Dürre
Formation of solvents in clostridia; Dürre
VI. Special Groups and Ecosystems
Bacteriophages of Clostridium; Jones
Acetogenic clostridia; Drake and Küsel
Halophilic clostridia; Oren
Syntrophism among clostridiales; Plugge and Stams
Ecology and activity of clostridia in the intestine of mammals; Konstantinov, Smidt, and Akkermans
VII. Novel Developments and Applications
Industrially relevant fermentations; Ezeji, Qureshi, Cotta, and Blaschek
Metabolic engineering of solventogenic clostridia; Tomas, Tummala, and Papoutsakis
Biodegradation of hazardous materials by clostridia; Ahmad, Hughes, and Bennett
Clostridial collagenase in wound repair; Brett
Clostridia as production systems for prokaryotic and eukaryotic proteins of therapeutic value in tumor treatment; Van Mellaert, Theys, Pennington, Barbé, Nuyts, Landuyt, Lambin, Minton, and Anné
Editorial Reviews
"Considering the depth and thoroughness with which the volume was assembled, it will be quite a valuable resource for graduate students, research microbiologists, medical microbiologists, industrial biotechnologists, and toxicologists."
-Stephen Melville, Quarterly Review of Biology, Vol. 81, No. 2, 2006
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