Parkinson's Disease
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Summary
Recent research is leading to an ever-increasing range of investigative approaches whose aim is to achieve effective neuroprotective or neurorestorative treatment for individuals affected by Parkinson’s disease. New directions under investigation reach beyond traditional pharmacological approaches to venture into innovative surgical methods, gene therapy, stem cell therapy, and neurotransplantation.
In this comprehensive volume, leading medical authorities provide state-of-the-art information on all aspects of Parkinson’s disease. They cover the historical background, neuropathological and neurophysiological characteristics, epidemiological aspects, clinical features, current treatment approaches, and potential therapeutic methods. Novel models are included to simplify more complex concepts.
Table of Contents
I. OVERVIEW
James Parkinson, Jennifer G. Goldman and Christopher G. Goetz
Paralysis Agitans – Refining the Diagnosis and Treatment, Larry Elmer
The Role of Dopamine in Parkinson’s Disease: An Historical Review, L. Charles Murrin
Parkinson’s Disease: Where Are We?, Ajit Kumar, Zhigao Huang, and Donald B. Calne
II. EPIDEMIOLOGY
Epidemiology of Parkinson’s Disease: An Overview, Monica Korell and Caroline M. Tanner
Environmental Toxins and Parkinson’s Disease, Marcia H. Ratner and Robert G. Feldman
Rural Environment and Parkinson’s Disease, Daniel Strickland
Industrial and Occupational Exposures and Parkinson’s Disease, Brad A. Racette
Tetrahydroisoquinolines and Parkinson’s Disease, Mark S. LeDoux
Xenobiotic Metabolism and Idiopathic Parkinson’s Disease, L. Cartwright, D.B. Ramsden, S.W. Smith, R.H. Waring, R.B. Parsons, S.L. Ho, and A.C. Williams
Progressive Neurodegeneration in the Chronic MPTP/Probenecid Model of Parkinson’s Disease, Yuen-Sum Lau
III. GENETICS
Alpha Synuclein and Parkinson’s Disease, Lawrence I. Golbe
Parkin and It’s Role in Parkinson’s Disease, Thomas Gasser
Heredofamilial Parkinsonism, Pramod Kumar Pal and Zbigniew K. Wszolek
Other Mutations: Their Role in Parkinson Disease, Nathan Pankratz and Tatiana Foroud
IV. CLINICAL FEATURES OF PARKINSON’S DISEASE
Classical Motor Features of Parkinson’s Disease, Kelvin L. Chou and Howard I. Hurtig
Clinical Evaluation and Treatment of Gait Disorders in Parkinson’s Disease, Yacov Balash, Jeffery M. Hausdorff, Nir Giladi
A. Non-Motor Symptoms
Sensory Symptoms and Sensorimotor Distortion in Parkinson’s Disease, Padraig O’Suilleabhain
Pain in Parkinson’s Disease, Blair Ford
Fatigue: A Common Comorbidity in Parkinson’s Disease, Carol Ewing Garber and Joseph H. Friedman
Sleep Disorders in Parkinson’s Disease, Svenja Happe and Claudia Trenkwalder
Visual Function in Parkinson’s Disease, Robert L. Rodnitzky
Visuocognitive Dysfunctions in Parkinson’s Disease, Andrea Antal, Walter Paulus, and Ivan-Bodis Wollner
Olfactory Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes, Katerina Markopoulou
B. Autonomic Dysfunction
Gastrointestinal Dysfunction in Parkinson’s Disease, Ronald F. Pfeiffer
Urinary Dysfunction in Parkinson’s Disease, Carlos Singer
Sexual Dysfunction, Cheryl Waters and Janice Smolowitz
Cardiovascular Automomic Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes, Christopher Mathias
Disorders of Thermoregulation in Parkinson’s Disease, Thomas L. Davis
Respiratory Dysfunction, Holly Shill
C. Behavioral Dysfunction
Depression in Parkinson’s Disease, Steven P. Wengel, Daryl Bohac , and William J. Burke
Anxiety and Parkinson’s Disease, Oksana Suchowersky and Michael Trew
Dementia in Parkinson’s Disease, Anne L. Barba , Eric S. Molho, Donald S. Higgins, Anthony J. Santiago, and Stewart A. Factor
V. PATHOPHYSIOLOGY OF PARKINSON’S DISEASE
Animal Models of Basal Ganglia Injury and Degeneration and Their Application to Parkinson’s Disease Research, Giselle M. Petzinger and Michael W. Jakowec
The Neuropathology of Parkinson’s Disease and Other Parkinsonian Disorders, Christopher A. Robinson and Ali H. Rajput
Pathophysiology of Motor Disorder, Gaetan Garraux and Mark Hallett
A. Neurochemical Pathology
MPTP Disrupts Dopamine Receptors and Dopamine Transporters, Manuchair Ebadi and Jaturaporn Chagkutip
Pathophysiology of Parkinson’s Disease, Neurochemical Pathology: Other Transmitters, Yoshikuni Mizuno
B. Theories of Pathogenesis
Metallothionein Isoforms Attenuate Peroxynityrite-Induced Oxidative Stress in Parkinson’s Disease, Manuchair Ebadi, Sushil Sharma, Sawitri Wanpen, and Shaik Shavali
Excitotoxicity in Parkinson’s Disease, James G. Greene and J. Timothy Greenamyre
Inflammation, Roger Kurlan
Cell Death in Parkinson’s Disease, Ciaran J. Faherty and Richard J. Smeyne
Weaver Mutant Mouse in Progression of Neurodegeneration in Parkinson’s Diseae, Maunchair Ebadi, Sushil Sharma, Amornpan Ajjimapon, and Scott Manum
VI. DIAGNOSIS OF PARKINSON’S DISEASE
Differential Diagnosis of Parkinson’s Disease, Serena W. Hung. and Anthony E. Lang
Diagnostic Criteria for Parkinson’s Disease, Daniel Tarsy
Neuroleptic-Induced Movement Disorders, Manuchair Ebadi
The Placebo Effect in Parkinson’s Disease, Sarah C. Lidstone, Raul de la Fuente-Fernandez, and A. Jon Stoessl
Dopamine Transporter Imaging Using SPECT in Parkinson’s Disease, Danna Jennings, Ken Marek, and John Seibyl
MR Imaging of Parkinsonism, James Wood
Clinical Batteries, Erwin B. Montgomery, Jr.
Rating Scales, Kathleen M. Shannon
VII. TREATMENT OF PARKINSON’S DISEASE
A. Symptomatic Medical Treatment
Treatment of Parkinson’s Disease with Anticholinergic Medications, Bahman Jabbari and Rene Pazdan
Amantadine, Kelly E. Lyonsand Rajesh Pahwa
The Role of MAO-B Inhibitors in the Treatment of Parkinson’s Disease, John Bertoni and Larry Elmer
Catechol-O-Methyltransferase Inhibitors in the Treatment of Parkinson’s Disease, Mervat Wahba, Theresa A. Zesiewicz, and Robert A. Hauser
Symptomatic Treatment of Parkinson’s Disease: Levodopa, John L. Goudreau and J. Eric Ahlskog
Dopamine Agonists in Parkinson’s Disease, Sandra Kuniyoshi and Joseph Jankovic
B. Surgical Treatment
Parkinson’s Disease: Surgical Treatment – Stereotactic Procedures, Yasuhiko Baba, Robert E. Wharen, Jr., and Ryan J. Uitti
Neurotransplanation in Parkinson’s Disease, Ronald F. Pfeiffer
C. Non-Pharmacological Treatment Modalities
The Role of Physical Therapy in Management of Parkinson’s Disease, Rose Wichmann
Swallowing Function in Parkinson’s Disease, Lisa A. Newman
Restorative and Psychosocial Occupational Therapy in Parkinson’s Disease. Surya Shah and Ann Nolen
Music Therapy for People with Parkinson’s, Sandra L. Holten
D. Treatment Issues
Pathogenesis of Motor Response Complications in Parkinson’s Disease: “Mere Conjectural Suggestions” and Beyond, Leo Verhagen Metman
Treatment of Early Parkinson’s Disease, John C. Morgan and Kapil D. Sethi
Moderate Parkinson’s Disease , John E. Duda and Matthew B. Stern
Management of Advanced Parkinson’s Disease, James W. Tetrud
E. Potential Future Therapy
Future Symptomatic Therapy in Parkinson’s Disease, Ruth Djaldetti and Eldad Melamed
Restorative Therapy in Parkinson’s Disease, Joel M. Trugman
Gene Therapy for Parkinson’s Disease, Ronald J. Mandel, Edgardo Rodriguez, M. Angela Cenci, Stuart E. Leff, Fredric Manfredsson, and Carmen S. Peden
Translating Stem Cell Biology to Regenerative Medicine for Parkinson’s Disease, Dennis A. Steindler
F. Clinical Trials
Alternative Drug Delivery in the Treatment of Parkinson’s Disease, Pierre J. Blanchet
The Role and Design of Clinical Trials for Parkinson’s Disease, Andrew Siderowf and Stanley Fahn
Positron Emission Tomography in Parkinson’s Disease, John R. Adams and A. Jon Stoessl
VIII. SOCIAL ISSUES IN PARKINSON’S DISEASE
Economics of Parkinson’s Disease, Katia Noyes and Robert G. Holloway
Informal Caregivers: A Valuable Part of the Health Care Team, Kirsten Maier and Susan Calne
Quality of Life in Parkinson’s Disease: A Conceptual Model, Mickie D. Welsh
The Evolution and Potential of the National Parkinson Organizations: A Brief Overview, Ruth A. Hagestuen
Editorial Reviews
“… brought together experts from across the vast field of PD research to create an invaluable reference, outlining our current understanding of this disease. With 78 chapters across 8 primary themes, this massive text contains all the information that any student new to the field requires to develop a thorough understanding of PD. With chapters about everything form epidemiology, to theories of pathogenesis, and back to symptoms and treatment, this book covers the entire range of what we can know about a biological phenomenon, from the molecular, cellular and genetic levels, through to the whole human being and the entire human population. … Overall, this book is truly a success. Extremely broad in its coverage of the topic, and generally very well written, and in a way that is accessible to both seasoned veterans of Parkinson’s research, looking for the last information in an area outside their direct expertise, and novices, trying to grasp an understanding of the extent of our current knowledge of PD.”
— Elissa M. Strome, Department of Experimental Medical Science, Lund University, Sweden, in the Journal of Chemical Neuroanatomy, Vol. 33, No. 4, February 2007
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”I would recommend it highly to those with a specialist’s interest in Parkinson’s disease and to more general neurologists who want an accessible, readable guide to diagnosing and treating this disease.”
New England Journal of Medicine, September 2005
”…tightly constructed and well organized. It stands out as the most comprehensive volume available on this disorder.”
JAMA, Volume 293, 2005
“A new encyclopedic collection of clinical wisdom…the largest and most comprehensive of several reference books that focus on this illness….masterfully organized.”
Parkinson’s Disease Update, Issue 145, 2005
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