Drug Delivery Systems, Second Edition

Published:
August 26, 2003 by CRC Press - 464 Pages
Author(s):
Vasant V. Ranade, Director of Chemical Research, Academic Pharmaceuticals Inc, Lake Bluff, IL; Mannfred A. Hollinger, University of California, Davis, USA; John B. Cannon, Targeted Drug Solutions, Grayslake, IL

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Hardback
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ISBN 9780849314339
Cat# 1433
 

Features

  • Covers the latest developments in all areas of drug delivery systems
  • Presents the information in a simple, straightforward, clear, and concise manner
  • Provides a global perspective for present and future advances and market opportunities
  • Contains input from Wall Street and other global financial institutions
  • Includes strategies for dealing effectively with regulatory agencies around the world

    • Summary

    Drug delivery technologies represent a vast and vital area of Research and Development. The demand for innovative drug delivery systems continues to grow, and this growth continues to drive new developments.

    Building on the foundation provided by the first edition, Drug Delivery Systems, Second Edition covers the latest developments in both industry and academia.

    New in this edition:

  • Chapter focusing on novel technologies and their global outlook
  • Coverage of electronically controlled drug delivery
  • Macrocapsules and nanoparticles in drug targeting
  • Drug nanocrystals and other new delivery systems
  • Updated information on liposomes as carriers

    Written in a straightforward, clear, and concise manner, the author provides a global perspective on current and future advances and market opportunities. Drug Delivery Systems, Second Edition answers the need for comprehensive information in a single resource for anyone venturing into this area of drug development.

    • Table of Contents

    SITE-SPECIFIC DRUG DELIVERY
    Site-Specific Drug Delivery Using Liposomes as Carriers
    Introduction
    Liposomes in Drug Delivery
    The Liposome-Drug Concept
    Liposomes as Carriers of Therapeutic Agents
    Recent Advances
    Concluding Remarks

    Site Specific Drug Delivery Utilizing Monoclonal Antibodies
    Introduction
    Production of Monoclonal Antibodies
    Drug-Monoclonal Antibody Conjugates for Drug Targeting
    Recent Studies with Monoclonal Antibodies
    Conclusion and Basis for Future Trends
    References

    POLYMERS, IMPLANTABLE DRUG DELIVERY
    Role of Polymers in Drug Delivery
    Introduction
    Currently Available Polymers
    Soluble Polymers
    Biodegradable or Bioerodible Polymers
    Mucoadhesive Polymers
    Polymers Containing Pendant Substituents
    Matrix Systems
    Heparin Releasing Polymers
    Ionic Polymers
    Oligomers
    Miscellaneous
    Recent Advances
    Conclusion

    Implants in Drug Delivery
    Introduction
    Insulin Delivery as a Model Implant Pump System
    Implants for Contraception

    ORAL DRUG DELIVERY
    Oral Drug Delivery
    Introduction
    Features of the GI Tract
    Targeting of Drugs in the GI Tract
    Design and Fabrication of Oral Delivery systems
    Survey of Oral Controlled Release Products
    Recent Advances
    Conclusion
    References

    TRANSDERMANL, INTRANASAL, OCULAR, AND MISCELLANEOUS DRUG DELIVERY
    Transdermal Drug Delivery
    Introduction
    Structure of Human Skin
    Theoretical Advantages of the Transdermal Route
    Optimization of Percutaneous Absorption
    Theory for Penetration-Enhancer Activity
    Development of the Transdermal Therapeutic System
    Examples of Transdermal Applications
    Transdermal Controlled-Release Products and Devices
    Recent Advances
    Conclusion
    References

    Intranasal and Ocular Drug Delivery
    Intranasal Drug Delivery
    Ocular Drug Delivery
    References

    Miscellaneous Forms of Drug Delivery
    Introduction
    Prodrugs
    Infusion Devices
    Insulin Delivery
    Parenteral Prolonged Action Dosage Forms
    Summary

    REGULATORY CONSIDERATIONS AND GLOBAL OUTLOOK
    Regulatory Considerations for Drug Delivery Systems
    Introduction
    Current Status of Drug Delivery Technology
    Submission of Documents for Manufacture and Quality

    Drug Delivery Industry and the Global Outlook

    INDEX

    Editorial Reviews

    "The second edition of this book in the very popular CRC Press series on Pharmacology and Toxicology serves as an excellent review source on current information on drug delivery systems. … The book is well organized in that each chapter provides the reader with a table of products marketed and currently under investigation … This book has been successful in condensing a large volume of information … This book belongs on the shelves of pharmaceutical scientists as a short reference guide to the discipline. Students will also find this text useful for surveying the broad topic of drug delivery systems in a relatively small volume."
    - Pharmaceutical Research, Vol. 21, No. 6, June 2004


    "…an excellent introduction and review of an important field that greatly contributes to medical therapeutics. … The material is well-referenced and a most comprehensive review of an interesting and important field. … filled with practical examples and potential future directions. The chapter on oral drug delivery system especially sustained release technologies is most important and well presented. …This is highly recommended reading for those individuals in drug development…"
    --J. Somberg, American Journal of Therapeutics

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