A wide variety of biomedical photonic technologies have been developed recently for clinical monitoring of early disease states; molecular diagnostics and imaging of physiological parameters; molecular and genetic biomarkers; and detection of the presence of pathological organisms or biochemical species of clinical importance. However, available information on this rapidly growing field is fragmented among a variety of journals and specialized books.
Now researchers and medical practitioners have an authoritative and comprehensive source for the latest research and applications in biomedical photonics. Over 150 leading scientists, engineers, and physicians discuss state-of-the-art instrumentation, methods, and protocols in the Biomedical Photonics Handbook. Editor-in-Chief Tuan Vo-Dinh and an advisory board of distinguished scientists and medical experts ensure that each of the 65 chapters represents the latest and most accurate information currently available.
1. Biomedical Photonics: A Revolution at the Interface of Science and Technology, T. Vo-Dinh
PHOTONICS AND TISSUE OPTICS
2. Optical Properties of Tissues, J. Mobley and T. Vo-Dinh
3. Light-Tissue Interactions, V.V. Tuchin
4. Theoretical Models and Algorithms in Optical Diffusion Tomography, S.J. Norton and T. Vo-Dinh
PHOTONIC DEVICES
5. Laser Light in Biomedicine and the Life Sciences: From the Present to the Future, V.S. Letokhov
6. Basic Instrumentation in Photonics, T. Vo-Dinh
7. Optical Fibers and Waveguides for Medical Applications, I. Gannot and M. Ben David
8. Biological Imaging Spectroscopy, G. Bearman and R. Levenson
PHOTONIC DETECTION AND IMAGING TECHNIQUES
9. Lifetime-Based Imaging, P. Herman, H.-J. Lin, and J.R. Lakowicz
10. Confocal Microscopy, T. Wilson
11. Two-Photon Excitation Fluorescence Microscopy, P.T.C. So, C.Y. Dong, and B.R. Masters
12. Near-Field Imaging in Biological and Biomedical Applications, V. Deckert
13. Optical Coherence Tomography Imaging, J.G. Fujimoto and M. Brezinski
14. Speckle Correlometry, D.A. Zimnyakov and V.V. Tuchin
15. Laser Doppler Perfusion Monitoring and Imaging, G.E. Nilsson, E.G. Salerud, T. Stromberg, and K. Wardell
16. Light Scatter Spectroscopy and Imaging of Cellular and Subcellular Events, N.N. Boustany and N.V. Thakor
17. Thermal Imaging, J. Gore
BIOMEDICAL DIAGNOSTICS I
18. Glucose Diagnostics, G.L. Cote and R.J. McNichols
19. In Vitro Clinical Diagnostic Instrumentation, G. Cohn and R. Domanik
20. Biosensors for Medical Applications, T. Vo-Dinh and L. Allain
21. Functional Imaging with Diffusing Light, A.G. Yodh and D.A. Boas
22. Photon Migration Spectroscopy Frequency-Domain Techniques, A.E. Cerussi and B.J. Tromberg
23. Atomic Spectroscopy for Biological and Clinical Analysis, A. Taylor
24. Capillary Electrophoresis Techniques in Biomedical Analysis, S.D. Gilman and M.J. Sepaniak
25. Flow Cytometry, Francis Mandy, R. Varro and D. Recktenwald
26. X-Ray Diagnostic Techniques, X. Wu, A.E. Deans, and H. Liu
27. Optical Pumping and MRI of Hyperpolarized Spins, X. Wu, T. Nishino, and H. Liu
BIOMEDICAL DIAGNOSTICS II: OPTICAL BIOPSY
28. Fluorescence Spectroscopy for Biomedical Diagnostics, T. Vo-Dinh and B.M. Cullum
29. Elastic-Scattering Spectroscopy and Diffuse Reflectance, J.R. Mourant and I.J. Bigio
30. Raman Spectroscopy: From Benchtop to Bedside, A. Mahadevan-Jansen
31. Quantitative Characterization of Biological Tissue Using Optical Spectroscopy, I. Georgakoudi, J. Motz, V. Backman, G. Angheloiu, A. Haka, M. Muller, R. Dasari, and M.S. Feld
32. Recent Developments in Fourier Transform Infrared (FTIR) Microspectroscopic Methods for Biomedical Analyses: From Single Point Detection to Two-Dimensional Imaging, R. Bhargava and I.W. Levin
33. Near Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues, E.M. Sevick-Muraka, E. Kuwana, A. Godavarty, J.P. Houston, A.B. Thompson, and R. Roy
34. Optoacoustic Tomography, A.A. Oraevsky and A.A. Karabutov
35. Ultrasonically Modulated Optical Imaging, J. Selb, S. Leveque-Fort, A. Dubois, B.C. Forget, L. Pottier, F. Ramaz, and C. Boccara
THERAPEUTIC AND INTERVENTIONAL TECHNIQUES
36. Mechanistic Principles of Photodynamic Therapy, B.W. Henderson and S.O. Gollnick
37. Synthetic Strategies in Designing Porphyrin-Based Photosensitizers for Photodynamic Therapy, R.K. Pandey
38. Photodynamic Therapy (PDT) and Clinical Applications, T.J. Dougherty and J.G. Levy
39. Laser Tissue Welding, K.M. McNally-Heintzelman and A.J. Welch
40. Lasers in Dermatology, K. Suthamjariya and R.R. Anderson
41. Lasers in Interventional Pulmonology, A.N. Mathur and P.N. Mathur
42. Lasers in Neurosurgery, D.K. Binder, M.H. Schmidt, R. Du, and M.S. Berger
43. Lasers in Ophthalmology, E. Maguen, T.G. Chu, and D. Boyer
44. Lasers in Otolaryngology, L. Reinish
45. Lasers in Urology, J.T. Leyland II, D.F. Albrecht, and S.H. Selman
46. Therapeutic Applications of Lasers in Gastroenterology, M. Panjehpour and B.F. Overholt
47. Laser Treatment of Breast Tumors, G.M. Briggs, A. Lee, and S.G. Bown
48. Low-Power Laser Therapy, T.I. Karu
49. Image Guided Surgery, R.D. Bucholz and K.A. Laycock
50. Lasers in Dentistry, D. Fried
ADVANCED BIOPHOTONICS FOR GENOMICS, PROTEOMICS AND MEDICINE
51. Biochips and MicroArrays: Tools for the New Medicine, T. Vo-Dinh
52. Array Technologies and Multiplex Genetic Analysis, Y. Wang, C. Virgos, S. Singh, M.T. Cronin, S.J. Williams, and E.S. Mansfield
53. DNA Sequencing using Fluorescence Detection, S.A. Soper, C.V. Owens, S.J. Lassiter, Y. Xu, and E. Waddell
54. Living Cell Analysis Using Optical Methods, P.M. Viallet and T. Vo-Dinh
55. Amplification Technologies for Optical Detection (PCR, hybrid SDA, FRET), G.D. Griffin, M.W. Williams, D.N. Stratis-Cullum, and T. Vo-Dinh
56. Fluorescent Probes in Biomedical Applications, D.J. Bornhop and K. Licha
57. Novel Fluorescent Molecular Beacon DNA Probes for Biomolecular Recognition, W. Tan, K. Wang, J. Li, X. Fang, S. Shuster, S. Kelley, H. Lou, J.J. Li, T. Beck, and R. Hogrefe
58. Luminescent Quantum Dots as Ultrasensitive and Multicolor Biological Labels, W.C.W. Chan and S. Nie
59. PEBBLE Nanosensors for In Vitro Bioanalysis, Eric Monson, M. Brasuel, M.A. Philbert, and R. Kopelman
60. Nanosensors for Single-Cell Analysis, B.M. Cullum and T. Vo-Dinh
61. Optical Trapping Techniques in Bioanalysis, K. Yasuda
62. In Vivo Bioluminescence Imaging as a Tool for Drug Development, C.H. Contag and P.R. Contag
63. Liposome-Based Systems for Biomedical Diagnostics and Therapy, T. Nguyen, G. Dumitrascu, and Z. Rosenzweig
64. Surface-Enhanced Raman Scattering (SERS) for Biomedical Diagnostics, T. Vo-Dinh and D.L. Stokes
APPENDIX
65. Spectroscopic Data in Biologically and Medically Relevant Species and Samples, D.N. Stratis-Cullum, D.L. Stockes, B.M. Cullum, J. Myong Song, P.M. Kasili, R. Jagannathan, J. Mobley, and T. Vo-Dinh
"New optical technologies, many involving lasers or nanotechnologies providing sensitive and compact electronic-like devices, are revolutionizing many fields. Applications of new optical technologies to biology and medicine might be described as in an adolescent stage, where their power and potential can be recognized but are still developing rapidly, and much is yet to come. The Biomedical Photonics Handbook provides outstanding coverage of basic ideas, present applications of these new technologies, and future potentials. The manifold aspects of the field are discussed by a remarkable selection of experts. This handbook can be expected to be a much used and standard reference during the inevitably rapid development of biological and medical photonics."
-Charles H. Townes, Nobel Prize in Physics, 1964, Co-inventor of the Laser
"This straightforward, well-organized book is an excellent reference that consolidates a wealth of information of interest to anyone involved in biophotonics research, teaching, learning or practice."
- Optics and Photonics News, Vol. 15, No. 12, December 2004