Biomedical Photonics Handbook

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  • Provides the first comprehensive look at a flourishing area at the intersection of technology and medicine
  • Defines the field of biomedical photonics for all academic, governmental, and industrial researchers
  • Covers optical techniques for diagnosis, therapy, and prevention of disease
  • Provides introductory material in each chapter, including an overview of the topic, a collection of published data, and an extensive list of references for further reading
  • Includes optical detection technologies used in DNA and protein sequencing, gene diagnostics, and gene expression
  • Examines aspects of analytical chemistry and molecular biology important to biomedical diagnostics and therapy
  • Compiles useful information on spectroscopic data of biologically and medically relevant species for over 1000 compounds and systems in the Appendix
  • Offers bibliographic citations from hundreds of peer-reviewed scientific sources and journals
  • Includes over 1500 pages with thousands of diagrams, illustrations, figures, photographs, and equations INSIDE
  • Summary

    A wide variety of biomedical photonic technologies have been developed recently for clinical monitoring of early disease states; molecular diagnostics and imaging of physiological parameters; molecular and genetic biomarkers; and detection of the presence of pathological organisms or biochemical species of clinical importance. However, available information on this rapidly growing field is fragmented among a variety of journals and specialized books.

    Now researchers and medical practitioners have an authoritative and comprehensive source for the latest research and applications in biomedical photonics. Over 150 leading scientists, engineers, and physicians discuss state-of-the-art instrumentation, methods, and protocols in the Biomedical Photonics Handbook. Editor-in-Chief Tuan Vo-Dinh and an advisory board of distinguished scientists and medical experts ensure that each of the 65 chapters represents the latest and most accurate information currently available.

    Table of Contents

    1. Biomedical Photonics: A Revolution at the Interface of Science and Technology, T. Vo-Dinh


    2. Optical Properties of Tissues, J. Mobley and T. Vo-Dinh
    3. Light-Tissue Interactions, V.V. Tuchin
    4. Theoretical Models and Algorithms in Optical Diffusion Tomography, S.J. Norton and T. Vo-Dinh


    5. Laser Light in Biomedicine and the Life Sciences: From the Present to the Future, V.S. Letokhov
    6. Basic Instrumentation in Photonics, T. Vo-Dinh
    7. Optical Fibers and Waveguides for Medical Applications, I. Gannot and M. Ben David
    8. Biological Imaging Spectroscopy, G. Bearman and R. Levenson


    9. Lifetime-Based Imaging, P. Herman, H.-J. Lin, and J.R. Lakowicz
    10. Confocal Microscopy, T. Wilson
    11. Two-Photon Excitation Fluorescence Microscopy, P.T.C. So, C.Y. Dong, and B.R. Masters
    12. Near-Field Imaging in Biological and Biomedical Applications, V. Deckert
    13. Optical Coherence Tomography Imaging, J.G. Fujimoto and M. Brezinski
    14. Speckle Correlometry, D.A. Zimnyakov and V.V. Tuchin
    15. Laser Doppler Perfusion Monitoring and Imaging, G.E. Nilsson, E.G. Salerud, T. Stromberg, and K. Wardell
    16. Light Scatter Spectroscopy and Imaging of Cellular and Subcellular Events, N.N. Boustany and N.V. Thakor
    17. Thermal Imaging, J. Gore


    18. Glucose Diagnostics, G.L. Cote and R.J. McNichols
    19. In Vitro Clinical Diagnostic Instrumentation, G. Cohn and R. Domanik
    20. Biosensors for Medical Applications, T. Vo-Dinh and L. Allain
    21. Functional Imaging with Diffusing Light, A.G. Yodh and D.A. Boas
    22. Photon Migration Spectroscopy Frequency-Domain Techniques, A.E. Cerussi and B.J. Tromberg
    23. Atomic Spectroscopy for Biological and Clinical Analysis, A. Taylor
    24. Capillary Electrophoresis Techniques in Biomedical Analysis, S.D. Gilman and M.J. Sepaniak
    25. Flow Cytometry, Francis Mandy, R. Varro and D. Recktenwald
    26. X-Ray Diagnostic Techniques, X. Wu, A.E. Deans, and H. Liu
    27. Optical Pumping and MRI of Hyperpolarized Spins, X. Wu, T. Nishino, and H. Liu


    28. Fluorescence Spectroscopy for Biomedical Diagnostics, T. Vo-Dinh and B.M. Cullum
    29. Elastic-Scattering Spectroscopy and Diffuse Reflectance, J.R. Mourant and I.J. Bigio
    30. Raman Spectroscopy: From Benchtop to Bedside, A. Mahadevan-Jansen
    31. Quantitative Characterization of Biological Tissue Using Optical Spectroscopy, I. Georgakoudi, J. Motz, V. Backman, G. Angheloiu, A. Haka, M. Muller, R. Dasari, and M.S. Feld
    32. Recent Developments in Fourier Transform Infrared (FTIR) Microspectroscopic Methods for Biomedical Analyses: From Single Point Detection to Two-Dimensional Imaging, R. Bhargava and I.W. Levin
    33. Near Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues, E.M. Sevick-Muraka, E. Kuwana, A. Godavarty, J.P. Houston, A.B. Thompson, and R. Roy
    34. Optoacoustic Tomography, A.A. Oraevsky and A.A. Karabutov
    35. Ultrasonically Modulated Optical Imaging, J. Selb, S. Leveque-Fort, A. Dubois, B.C. Forget, L. Pottier, F. Ramaz, and C. Boccara


    36. Mechanistic Principles of Photodynamic Therapy, B.W. Henderson and S.O. Gollnick
    37. Synthetic Strategies in Designing Porphyrin-Based Photosensitizers for Photodynamic Therapy, R.K. Pandey
    38. Photodynamic Therapy (PDT) and Clinical Applications, T.J. Dougherty and J.G. Levy
    39. Laser Tissue Welding, K.M. McNally-Heintzelman and A.J. Welch
    40. Lasers in Dermatology, K. Suthamjariya and R.R. Anderson
    41. Lasers in Interventional Pulmonology, A.N. Mathur and P.N. Mathur
    42. Lasers in Neurosurgery, D.K. Binder, M.H. Schmidt, R. Du, and M.S. Berger
    43. Lasers in Ophthalmology, E. Maguen, T.G. Chu, and D. Boyer
    44. Lasers in Otolaryngology, L. Reinish
    45. Lasers in Urology, J.T. Leyland II, D.F. Albrecht, and S.H. Selman
    46. Therapeutic Applications of Lasers in Gastroenterology, M. Panjehpour and B.F. Overholt
    47. Laser Treatment of Breast Tumors, G.M. Briggs, A. Lee, and S.G. Bown
    48. Low-Power Laser Therapy, T.I. Karu
    49. Image Guided Surgery, R.D. Bucholz and K.A. Laycock
    50. Lasers in Dentistry, D. Fried


    51. Biochips and MicroArrays: Tools for the New Medicine, T. Vo-Dinh
    52. Array Technologies and Multiplex Genetic Analysis, Y. Wang, C. Virgos, S. Singh, M.T. Cronin, S.J. Williams, and E.S. Mansfield
    53. DNA Sequencing using Fluorescence Detection, S.A. Soper, C.V. Owens, S.J. Lassiter, Y. Xu, and E. Waddell
    54. Living Cell Analysis Using Optical Methods, P.M. Viallet and T. Vo-Dinh
    55. Amplification Technologies for Optical Detection (PCR, hybrid SDA, FRET), G.D. Griffin, M.W. Williams, D.N. Stratis-Cullum, and T. Vo-Dinh
    56. Fluorescent Probes in Biomedical Applications, D.J. Bornhop and K. Licha
    57. Novel Fluorescent Molecular Beacon DNA Probes for Biomolecular Recognition, W. Tan, K. Wang, J. Li, X. Fang, S. Shuster, S. Kelley, H. Lou, J.J. Li, T. Beck, and R. Hogrefe
    58. Luminescent Quantum Dots as Ultrasensitive and Multicolor Biological Labels, W.C.W. Chan and S. Nie
    59. PEBBLE Nanosensors for In Vitro Bioanalysis, Eric Monson, M. Brasuel, M.A. Philbert, and R. Kopelman
    60. Nanosensors for Single-Cell Analysis, B.M. Cullum and T. Vo-Dinh
    61. Optical Trapping Techniques in Bioanalysis, K. Yasuda
    62. In Vivo Bioluminescence Imaging as a Tool for Drug Development, C.H. Contag and P.R. Contag
    63. Liposome-Based Systems for Biomedical Diagnostics and Therapy, T. Nguyen, G. Dumitrascu, and Z. Rosenzweig
    64. Surface-Enhanced Raman Scattering (SERS) for Biomedical Diagnostics, T. Vo-Dinh and D.L. Stokes


    65. Spectroscopic Data in Biologically and Medically Relevant Species and Samples, D.N. Stratis-Cullum, D.L. Stockes, B.M. Cullum, J. Myong Song, P.M. Kasili, R. Jagannathan, J. Mobley, and T. Vo-Dinh

    Editorial Reviews

    "New optical technologies, many involving lasers or nanotechnologies providing sensitive and compact electronic-like devices, are revolutionizing many fields. Applications of new optical technologies to biology and medicine might be described as in an adolescent stage, where their power and potential can be recognized but are still developing rapidly, and much is yet to come. The Biomedical Photonics Handbook provides outstanding coverage of basic ideas, present applications of these new technologies, and future potentials. The manifold aspects of the field are discussed by a remarkable selection of experts. This handbook can be expected to be a much used and standard reference during the inevitably rapid development of biological and medical photonics."
    -Charles H. Townes, Nobel Prize in Physics, 1964, Co-inventor of the Laser

    "This straightforward, well-organized book is an excellent reference that consolidates a wealth of information of interest to anyone involved in biophotonics research, teaching, learning or practice."
    - Optics and Photonics News, Vol. 15, No. 12, December 2004


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