Methods in Alcohol-Related Neuroscience Research

Series:
Frontiers in Neuroscience
Published:
February 14, 2002 by CRC Press - 416 Pages
Editor(s):
Yuan Liu, National Institute of Neurological Disorders & Stroke, Bethesda, Maryland, USA; David M. Lovinger, Laboratory of Integrative Neuroscience, NIAAA, Nashville, Tennessee, USA

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Hardback
$169.95
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ISBN 9780849302039
Cat# 0347
 

Features

  • Covers cutting-edge methods, technologies, and approaches as applied to alcohol-related basic and clinical research
  • Provides an in-depth overview of up-to-date advances in the field
  • Includes descriptions and evaluations of the method, reviews of the theoretical background, examples of applications and comprehensive lists of references
  • Explores how the application of these methodologies will benefit other areas of neuroscience research

    • Summary

    Neuroscience research in alcohol-related disorders has made remarkable progress in the last two decades. The advances are due, in great part, to the large array of powerful biomedical, bioengineering, and computational biological techniques that are now employed.

    To date, there has not been a comprehensive text that covers recently developed methods in alcohol-related research. Methods in Alcohol-Related Neuroscience Research provides up-to-date technical guidance for investigators doing research at the molecular, cellular, systems, and behavioral levels. These techniques include a wide variety of approaches, ranging from gene mapping and examination of molecular interactions of alcohol at the sub-cellular level to recording of neural activities in freely-behaving animals and imaging alcohol effects on the living human brain.

    Written by a panel of experts, Methods in Alcohol-Related Neuroscience Research not only provides information of a technical nature but also gives an overview of the many areas in investigating the effects of alcohol on the brain.

    Table of Contents

    Quantitative Trait Locus (QTL) Mapping in Mice, A.A. Palmer and T.J. Phillips

    Knockout and Knockin Mice, G.E. Homanics

    Molecular Studies by Chimeragenesis and Mutagenesis, M.J. Beckstead, G.F. Lopreato, K.E. Vrana and S.J. Mihic

    Combining Patch-Clamp Recording and Gene Profiling in Single Neurons, H.H. Yeh, S. Therianos and S.-M. Lu

    Quantitative Analysis of Neurotransmitter Receptor Expression with Antibody-Based Techniques, C.F. Valenzuela and D.D. Savage

    Artificial Bilayer Techniques in Ion Channel Study, S.N. Treistman, R. O'Connell and J. Crowley

    Rapid Drug Superfusion and Kinetic Analysis, D.M. Lovinger, S. Sikes and Q. Zhou

    Electrophysiological Assessment of Synaptic Transmission in Brain Slices, J.L. Weiner

    Cognitive Correlates of Single Neuron Activity in Task-Performing Animals, B. Givens and T.M. Gill

    Multichannel Neural Ensemble Recording During Alcohol Self-Administration, P.H. Janak

    Combined Single-Neuron Recording and Microdialysis in the Brain of Freely Behaving Animals (Rodents and Non-Human Primates), N. Ludvig

    Quantitative Microdialysis for in vivo Studies of Pharmacodynamics, R.A. Gonzales, A.Tang, and D.L. Robinson

    Structural Magnetic Resonance Imaging (MRI) of the Human Brain, T.L. Jernigan

    Biochemical, Functional and Microstructural Magnetic Resonance Imaging (MRI), E. Adalsteinsson, E.V. Sullivan and A. Pfefferbaum

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