DNA Damage Recognition

Published:
September 19, 2005 by CRC Press - 872 Pages
Editor(s):
Wolfram Siede, University of North Texas, Fort Worth, USA; Paul W. Doetsch, Emory University School of Medicine, Atlanta, Georgia, USA

Purchasing Options

Hardback
$239.95
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ISBN 9780824759612
Cat# DK3110
 

Features

Richly illustrated with a wide array of figures and photographs, this guide—

  • Supplies an extensive bibliography at the end of each chapter
  • Discusses the theoretical aspects of DNA damage recognition
  • Details key concepts in the recognition of bulky DNA base damage, primarily in the context of pro- and eukaryotic nucleotide excision repair
  • Reviews the excision repair of non-bulky base damage and various aspects of damage recognition
  • Covers short-patch repair and the recognition and repair of single- and double-strand breaks
  • Summarizes DNA damage recognition mechanisms that are relevant for various regulatory responses in pro- and eukaryotes such as transcriptional regulation or checkpoint arrest
  • Analyzes the pathways of damage tolerance as a consequence of a combined recognition/accommodation process in chapters on replicational damage bypass and the structural features of translesion polymerases

    • Summary

    Stands as the most comprehensive guide to the subject—covering every essential topic related to DNA damage identification and repair.

    Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employed by cells to distinguish between damaged and undamaged sites and stimulate the appropriate repair pathways.

    about the editors...

    WOLFRAM SIEDE is Associate Professor, Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth.  He received the Ph.D. degree (1986) from Johann Wolfgang Goethe University, Frankfurt Germany.

    YOKE WAH KOW is Professor, Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia.  He received the Ph.D. degree (1981) from Brandeis University, Waltham, Massachusetts.

    PAUL W. DOETSCH is Professor, Departments of Biochemistry, Radiation Oncology, and Hematology and Oncology, and Associate Director for Basic Research, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia.  He received the Ph.D. degree (1982) from Temple University School of Medicine, Philadelphia, Pennsylvania.

    Table of Contents

    Mechanisms of Damage Recognition: Theoretical Considerations. UV Damage and Other Bulky DNA-adducts. Non-bulky Base Damage. Mismatch Repair. Replicational Bypass of DNA Lesions. DNA Strand Breaks. Perception of DNA Damage for Initiating Regulatory Responses

    Editorial Reviews

    “Many of the chapters stand as the best review and reference document currently available in their respective area. .... Researchers who need a thoughtful in-depth review of the most exciting areas in DNA damage recognition will find that this book will do the job.”
      — Samuel H. Wilson, National Institutes of Health, Bethesda,, writing in  ScienceDirect located at www.elsevier.com/locate/dnarepair,

    “In keeping with the title of the book, I found the chapters in which conscious efforts were made to specifically address the issue of damage recognition to be the most valuable ones. …The book is a worthwhile investment for readers interested specifically in damage recognition in DNA repair systems.”
    — Orlando D. Schärer, ChemBioChem, Vol. 7, No. 9, September 2006

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