Genomics and Proteomics in Nutrition

Series:
Nutrition and Disease Prevention
Published:
August 11, 2004 by CRC Press - 528 Pages
Editor(s):
Carolyn D. Berdanier, Professor Emerita, University of Georgia, Athens, USA; Naima Moustaid-Moussa, University of Tennessee, Knoxville, USA

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Hardback
$219.95
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ISBN 9780824754303
Cat# DK1138
 

Features

  • Applies innovations in microarray technology to clinical practice, this reference explores advances in our understanding of obesity, birth defects, and cancer
  • Investigates the latest proteomic studies for a clear understanding of the role of nutrients and drugs in nutrient and cellular metabolism
  • Presents selected examples showcasing the effect of phytochemicals on gene expression in different model systems
  • Identifies molecular markers associated with various disease states for improved diagnostic and treatment regimens
  • Familiarizes clinical investigators  with the day-to-day problems encountered in the design, implementation, and evaluation of microarray analysis of clinical samples and provides the background necessary to develop solutions to these problems

    • Summary

    With contributions from 66 world-renowned authorities on the subject, Genomics And Proteomics In Nutrition focuses on the effect of genetic expression on protein production, establishing links between gene expression and nutrition, the influence of micro- and macronutrients on cellular homeostasis, and the relationship between diet, genetic predisposition, and human disease.

    Shows how bioinformatics and functional genomic databases can transform molecular biology research using a yeast ELO2/ human HELO1 protein cloning example.

    A cutting-edge reference, Genomics and Proteomics in Nutrition reveals new applications and insights in nutrition science and explores tools for nutrition research in the post-genomic era.

    Table of Contents

    MOUSE MODELS OF HUMAN DISEASES AND GENE TRANSCRIPTION
    Genetic Modifiers in Rodent Models of Obesity, Y. Wang, P.M. Nishina and J. Naggert
    Quantitative TrAit Loci in obesity and TYPE II Diabetes in Rodents, J.H. Kim
    The Human Sweet Tooth and its Relationship to Obesity, A.H. McDaniel and D.R. Reed
    The Adipose Renin-Angiotensin System: Genetics, Regulation, and Physiologic Function, B.H. Voy, S. Kim, S. Urs, M. Derfus, Y.-R. Heo, R. Joshi, F. Massiera, M. Teboul, G. Aihaud, A. Quignard-Boulangé, and N. Moustaid-Moussa
    Regulation of Fat Synthesis and Adipogenesis, K.-H. Kim, M.J. Griffin, J.A. Villena, and H.S. Sul
    Transcriptional Regulation of Energy Metabolism in Liver, M.T. Nakamura,

    GENOMICS: LARGE SCALE ANALYSIS OF GENE EXPRESSION BY MICROARRAY
    Design and Analysis of Microarray Studies for Obesity Research, M.-Pierre St. Onge, G.P. Page, M. DeLuca, K. Zhang, K. Kim, S.B. Heymsfield, and D. Allsion
    Solving Clinical Problems in Nutrition Research with Microarrays, S. Smith
    Genomic Approaches to Understanding Vitamin D Action, J. Fleet
    Gene Expression Profiling in Adipose Tissue, N. Moustaid-Moussa
    Phytochemicals and Gene Expression, O. Mezei and N. Shay
    Gene Expression Profiling of Immune Cells: Application for Understanding Aging of Immune Cells, S.N. Han and S. Meydani
    Improving the Nutritional Value of Cereal Grains Using a Genomic Approach, L. Shi and T. Zhu

    PROTEOMICS: LARGE SCALE ANALYSIS OF PROTEIN EXPRESSION AND REGULATION
    Proteomics and Genomics in Health & Disease, J.A. Carroll and C.E. Mathews
    2D-Gel Proteomics Studies on Leukocytes, I.C. Gerling and M.J. Pabst
    Proteomics: Tools for Nutrition Research in the Post-Genomic Era, A. Grider
    Proteomic Analysis of the Adipocyte Secretome, Ibarrola
    Mass Spectrometry Strategies for Proteomic Studies, M. Belghazi and H. Rogniaux
    Bioinformatics Tools, S.M Lin, K.F. Johnson, and S.W. Kullman
    Statistical Principles for Analysis of Array Experiments, A.M. Saxton and E.B. Moser
    Index

    Editorial Reviews

    “The present volume includes twenty contributions of the authors’ selected specialists that present recent advances on this type of problems. The first part discusses the models of mice for the study of diseases and issues of genetic transcription. The second part is dedicated to the strictly genomic aspects. And, in the third part is included the most related to proteomics. … This book that will be an invaluable resource to scientists dedicated to the nutrition problems from a different viewpoint. ”
    — In the Journal of Physiology and Biochemistry, Vol. 62, No. 1, March 2006

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