Nutrients and Cell Signaling
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Summary
Cell signaling is at the core of most biological processes from the simplest to the most complex. In addition to unicellular organisms possessing the essential ability to receive inputs with regard to nutrient availability and noxious stimuli, the cells in multicellular organisms require signaling from adjacent, as well as distant cells to maintain normal internal function, including growth, differentiation, and homeostasis. Conversely, the etiology of many disease processes, such as those involving immune system dysfunction and tumor development, have been traced to aberrant cell signaling.
Nutrients and Cell Signaling, in presenting contributions from a wide array of experts in the field, fully delineates the role of nutrients in cell signaling. The text emphasizes broad concepts and covers all major groups of nutrients. Contributors discuss the role of carbohydrates, amino acids, lipids, vitamins, minerals, and trace elements in essential processes such as cell proliferation, immune function, and DNA repair.
The editors have organized the work to provide select examples organized under these contemporary research areas:
Nutrients and Cell Signaling answers the need in the post-genomic era, for an authoritative resource that provides an in-depth understanding of how these complex and dynamic biomolecular networks control cell function. Those professionals and students in molecular biology, nutrition, biochemistry, as well as any branch involved with cell signaling and function will find this book to be an invaluable tool in promoting both understanding and further inquiry.
Table of Contents
Nuclear receptors, transcription factors, and signaling cascades
NFkB-dependent signaling pathways, Xiaoxia Li
Steroid receptors and dietary ligands, M.N. Jacobs
Retinoid signaling, Dianne R. Soprano, Pu Qin, Kenneth J. Soprano
Regulation of cytokines and immune function by 1,25-dihydroxyvitamn D3 and its analogues, Evelyne van Etten, Annapaula Giuletti, Conny Gysemans, Annemieke Verstuyf, Lut Overbergh, and Chantal Mathieu
Vitamin D regulated pathways: impact on cell proliferation, differentiation, and apoptosis, JoEllen Welsh
Effects of nutrient deprivation on the expression of growth-arrest genes, W.D. Rees
Mechanisms for dietary regulation of nitric oxide synthesis in mammals, Nick E. Flynn, Cynthia J. Meininger, Tony E. Haynes, Wenjuan Shi, and Guoyao Wu
The roles of thioredoxin reductases in cell signaling, Dan Su and Vadim N. Gladyshev
Roles for biotinylation of histones in chromatin structure, Gabriela Camporeale, Nagarama Kothapalli, Gautam Sarath, and Janos Zempleni
Amino acids, lipids, and glycation
Nutrient signaling to muscle and adipose tissue by leucine, Thomas C. Vary and Christopher J. Lynch
Anabolic effects of amino acids and insulin in the liver, Luc Bertrand and Louis Hue
Amino acid-sensing of mTOR signaling, Ebru Erbay, Jae Eun Kim, Jie Chen
Alterations in glutamate trafficking and signal transduction pathways in hyperammonemia, Helen Chan and Roger F. Butterworth
The influence of lipids on nuclear protein import, cell growth and gene expression, Randolph S. Faustino, Melanie N. Landry, Nicole T. Gavel, Michael P. Czubryt, and Grant N. Pierce
Isoprenoid regulation of the expression of RAS and RAS-related proteins, Sarah Holstein and Raymond J. Hohl
Amino acid signaling and the control of autophagy, Alfred J. Meijer, Peter F. Dubbelhuis, Edward F. C. Blommaart, and P. Codogno
A nutrient-sensing hexosamine signaling pathway, Dona Love and John A. Hanover
Insulin release, signaling, and insulin resistance
Insulin release, Mitsuhisa Komatsu
Metabolic actions of the glucagon-like peptides, Rhonda D. Wideman and Timothy J. Kieffer
Calcium-dependent signaling
Control of intracellular calcium levels, Shyamala Dakshinamurti, Jonathan Geiger, and Krishnamurti Dakshinamurti
Calcium-mediated signaling of neurons in the physiological and diseased state: role of endoplasmic reticulum, W. Paschen
Feeding and nutrient homeostasis
Within-meal feedback signaling, Jason C. G. Halford
The arcuate nucleus: its special place in the brain networks that control feeding behavior, Bernard Beck
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