Bacterial Resistance to Antimicrobials

Published:
November 21, 2001 by CRC Press - 528 Pages
Editor(s):
Richard G. Wax, Retired, Pfizer Global Research, Groton, Connecticut, USA; Kim Lewis, Northeastern University, Boston, Massachusetts, USA; Abigail A. Salyers, University of Illinois at Urbana Champaign, USA; Harry Taber, Wadsworth Center, Albany, New York, USA

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ISBN 9780824706357
Cat# DK6358
 

Summary

Focuses on combating bacterial pathogens by understanding their strategies of defense!

Each chapter begins with a summary of concepts, so those not actively working in the field gain an overall picture of what follows!

Highlights antibiotic resistance in pathogens that poses the greatest threat to human health!

Containing nearly 2000 references for additional research, Bacterial Resistance to Antimicrobials

  • discusses the ecology of drug resistance genes, acquired response, and selection in natural bacterial populations
  • describes global response systems that are a basis of resistance
  • details antibiotic modification, inactivation, and host target modification as means of resistance development
  • considers efflux mechanisms, one of the major causes of multidrug resistance
  • covers concepts for developing therapies against multidrug resistant organisms
  • emphasizes the structural basis of lactamases and other enzymes involved in inactivation of antibiotics
  • surveys the epidemiology of methicillin resistance among nosocomial isolates and community-acquired strains
  • outlines molecular detection methods for mainstream diagnostic tests
  • assesses the promise of modern genomics to identify novel targets for drug discovery screening

    Presenting the molecular basis, methods of detection and identification, and concepts for reducing the development and spread of resistant bacterial strains, Bacterial Resistance to Antimicrobials is an excellent reference for microbiologists, pharmacists, public health officials, infectious disease specialists, organic and medicinal chemists, and upper-level undergraduate and graduate students in these disciplines.

    • Table of Contents

    The Ecology of Antibiotic Resistance Genes
    Abigail A. Salyers, Nadja B. Shoemaker, and George T. Bonheyo

    Antibiotic Resistance: How Bacterial Populations Respond to a Simple Evolutionary Force
    Fernando de la Cruz, Juan M. García-Lobo, and Julian Davies

    Global Response Systems That Cause Resistance
    Paul F. Miller and Philip Rather

    Drug Efflux
    Kim Lewis and Olga Lomovskaya

    Mechanisms of Aminoglycoside Antibiotic Resistance
    Gerard D. Wright

    b-Lactamases and Resistance to b-Lactam Antibiotics
    Lakshmi P. Kotra, Jean-Pierre Samama, and Shahriar Mobashery

    Target Modification as a Mechanism of Antimicrobial Resistance
    David C. Hooper

    Antibiotic Permeability
    Harry W. Taber

    Phenotypic Tolerance of Bacteria
    Rodger Novak and Elaine I. Tuomanen

    Resistance as a Worldwide Problem
    Rosamund Williams

    Genetic Methods for Detecting Bacterial Resistance Genes
    Amalio Telenti and Fred C. Tenover

    Evolution and Epidemiology of Antibiotic-Resistant Pneumococci
    Christopher Gerard Dowson and Krzysztof Trzcinski

    Resistance Problems Associated with the Enterococcus
    George M. Eliopoulos

    Methicillin Resistance in Staphylococcus aureus Keeta S. Gilmore, Daniel F. Sahm, and Michael S. Gilmore

    Drug Resistance and Tuberculosis Chemotherapy-From Concept to Genomics
    Alexander S. Pym and Stewart T. Cole

    Antibiotic Resistance in Enterobacteria
    Nafsika H. Georgopapadakou

    Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings
    Richard E. Besser, Julia Y. Morita, and Scott K. Fridkin

    Approaches to New Antimicrobial Targets in the Age of Genomics
    Philip J. Youngman

    Index

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