Table of Contents

Free Radicals and Antioxidants in Brain Pathophysiology

The Role of Free Radicals in the Brain in Health and Disease in Relation to Synaptic Plasticity
John Smythies
Neuromodulatory Effects of Nitric Oxide in Pain Perception
Adalberto Merighi, Patrizia Aimar, Laura Lossi, Lucia Pasti, and Giorgio Carmignoto
Ischemic and Metabolic Stress-Induced Apoptosis
James David Adams, Jr., Lawrence R. Williams, Suman K. Mukherjee, Lori Klaidman, Glen Inouye, Vierka Cummins, and Maria Morales
Nitrogen Radicals in Ischemic Damage of the Brain
Tomris Özben
Neuroinflammatory Events and Enhanced Signal Transduction Processes Involved in Neurodegeneration
Robert A. Floyd, C. A. Stewart, K. A. Robinson, G. Bing, and K. Hensley

Free Radicals in Glutaate and Catecholamine-Mediated Neurotoxicity

Oxidative Stress in Glutamate Neurotoxicity
Derick S. Han, Enrique Cadenas, Michael S. Kobayashi, and Lester Packer
Modulation of Glutamate Release and Toxicity by Nitric Oxide
C. M. Carvalho, S. M. Sequeira, C. B. Duarte, and Ansélio P. Carvalho
Interplay Between Oxidative Stress and Calcium Homeostasis in Acute Neuronal Damage and Neurodegenerative Disease
Julie K. Andersen and Veena Viswanath
MAO Knockout Mice and Behavior
Jean Chen Shih, K. Chen, and M. J. Ridd
DNA Strand Breakage Induced by Nitric Oxide Together with Catecholamine: Implications for Neurodegenerative Diseases
Hiroshi Ohshima, Yumiko Yoshie, and Isabelle Gilibert
6-Hydroxydopamine, Dopamine, and Ferritin: A Cycle of Reactions Sustaining Parkinson's Disease?
G. N. L. Jameson and Wolfgang Linert

Free Radicals and Antioxidants in Neurological Disorders

ROS and Parkinson's Disease: A View to a Kill
Serge Przedborski and Vernice R. Jackson-Lewis
Nitric Oxide Overproduction and Oxidative Stress in Human Idiopathic Parkinson's Disease
Emilia Mabel Gatto, Natalia Andrea Riobó, Maria Cecilia Carreras, and Juan José Poderoso
Molecular and Cellular Aspects of Oxidative Damage in Alzheimer's Disease
Mark A. Smith and George Perry
Free Radical-Mediated Disruption of Cellular Ion Homeostasis, Mitochondrial Dysfunction, and Neuronal Degeneration in Sporadic and Inherited Alzheimer's Disease
Mark P. Mattson
Role of Transgenic Models for the Study of Oxidative Neurotoxicity in Alzheimer's Disease
Miguel A. Pappolla, Y.-J. Chyan, George Perry, Mark A. Smith, Melissa Sos, and Felix Cruz-Sanchez
Oxidative Protein Modification in Rosenthal Fibers: Implications for Alexander's Disease Pathogenesis
Rudolph J. Castellani, George Perry, and Mark A. Smith
Superoxide Dismutase and Amyotrophic Lateral Sclerosis
Giuseppe Rotilio, Alberto Ferri, Roberta Gabbianelli, and Maria Teresa Carrì Neurodegeneration and Antioxidant-Based Therapeutic Approaches

Effects of Ginko Biloba Extract (Egb 761) on Alzheimer's Disease
Yves Christen, Marie-Thérèse Droy-LeFaix, Catherine Pasquier, and Lester Packer
Glutathione and Metallothionein in Oxidative Stress of Parkinson's Disease
Manuchair Ebadi and Midori Hiramatsu
Estrogens and Other Antioxidants in Neuroprotection: Implications for Alzheimer's Disease
Christian Behl and Bernd Moosmann
Therapeutic Potential of Radical Scavengers in Parkinson's Disease
Silvia Mandel, Edna Grünblatt, and M. B. H. Youdim
Vitamin E and Other Antioxidant Treatments for the Neurobehavioral Aspects of Alzheimer's Disease and Other Neurodegenerative Disorders
Fadi Massoud, Mario Schittini, and Mary Sano
Nitric Oxide and the NMDA Receptor in Ischemia and Reperfusion Injury: Is NO Protective or Injurious?
Michael Graham Espey, Katrina M. Miranda, Carol A. Colton, Ryszard M. Pluta, Sandra J. Hewett, and David A. Wink
Endogenous Protection of Retinal Photoreceptors Against Light-Induced Oxidative Stress
Pier Lorenzo Marchiafava and Biancamaria Longoni