Free Radicals in Brain Pathophysiology

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ISBN 9780824703172
Cat# DK1595



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This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms.
Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity!
With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology

  • focuses on important biological signaling molecules such as superoxide anion and nitric oxide
  • evaluates the action of low levels of oxygen- and nitrogen-centered radicals on cell membranes and receptors to modulate signal transduction pathways and gene expression
  • links high mitochondrial density in neural tissue to brain disease
  • considers how prions and -amyloid proteins influence the level of free radicals within cells
  • assesses the abnormalities of superoxide dismutase in the familial form of amyotrophic lateral sclerosis
  • highlights the occurrence of oxidative stress and the impact of oxidative injury in brain physiology and neurodegeneration
  • and more!
    With contributions from nearly 70 internationally recognized researchers, physiologists, and clinicians who describe their latest findings and provide new insights into the factors underlying neurological disorders, Free Radicals in Brain Pathophysiology is an unsurpassed reference for nutritionists and dietitians, clinical neurologists, pathologists, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.
  • Table of Contents

    Free Radicals and Antioxidants in Brain Pathophysiology

    The Role of Free Radicals in the Brain in Health and Disease in Relation to Synaptic Plasticity
    John Smythies
    Neuromodulatory Effects of Nitric Oxide in Pain Perception
    Adalberto Merighi, Patrizia Aimar, Laura Lossi, Lucia Pasti, and Giorgio Carmignoto
    Ischemic and Metabolic Stress-Induced Apoptosis
    James David Adams, Jr., Lawrence R. Williams, Suman K. Mukherjee, Lori Klaidman, Glen Inouye, Vierka Cummins, and Maria Morales
    Nitrogen Radicals in Ischemic Damage of the Brain
    Tomris Özben
    Neuroinflammatory Events and Enhanced Signal Transduction Processes Involved in Neurodegeneration
    Robert A. Floyd, C. A. Stewart, K. A. Robinson, G. Bing, and K. Hensley

    Free Radicals in Glutaate and Catecholamine-Mediated Neurotoxicity

    Oxidative Stress in Glutamate Neurotoxicity
    Derick S. Han, Enrique Cadenas, Michael S. Kobayashi, and Lester Packer
    Modulation of Glutamate Release and Toxicity by Nitric Oxide
    C. M. Carvalho, S. M. Sequeira, C. B. Duarte, and Ansélio P. Carvalho
    Interplay Between Oxidative Stress and Calcium Homeostasis in Acute Neuronal Damage and Neurodegenerative Disease
    Julie K. Andersen and Veena Viswanath
    MAO Knockout Mice and Behavior
    Jean Chen Shih, K. Chen, and M. J. Ridd
    DNA Strand Breakage Induced by Nitric Oxide Together with Catecholamine: Implications for Neurodegenerative Diseases
    Hiroshi Ohshima, Yumiko Yoshie, and Isabelle Gilibert
    6-Hydroxydopamine, Dopamine, and Ferritin: A Cycle of Reactions Sustaining Parkinson's Disease?
    G. N. L. Jameson and Wolfgang Linert

    Free Radicals and Antioxidants in Neurological Disorders

    ROS and Parkinson's Disease: A View to a Kill
    Serge Przedborski and Vernice R. Jackson-Lewis
    Nitric Oxide Overproduction and Oxidative Stress in Human Idiopathic Parkinson's Disease
    Emilia Mabel Gatto, Natalia Andrea Riobó, Maria Cecilia Carreras, and Juan José Poderoso
    Molecular and Cellular Aspects of Oxidative Damage in Alzheimer's Disease
    Mark A. Smith and George Perry
    Free Radical-Mediated Disruption of Cellular Ion Homeostasis, Mitochondrial Dysfunction, and Neuronal Degeneration in Sporadic and Inherited Alzheimer's Disease
    Mark P. Mattson
    Role of Transgenic Models for the Study of Oxidative Neurotoxicity in Alzheimer's Disease
    Miguel A. Pappolla, Y.-J. Chyan, George Perry, Mark A. Smith, Melissa Sos, and Felix Cruz-Sanchez
    Oxidative Protein Modification in Rosenthal Fibers: Implications for Alexander's Disease Pathogenesis
    Rudolph J. Castellani, George Perry, and Mark A. Smith
    Superoxide Dismutase and Amyotrophic Lateral Sclerosis
    Giuseppe Rotilio, Alberto Ferri, Roberta Gabbianelli, and Maria Teresa Carrì Neurodegeneration and Antioxidant-Based Therapeutic Approaches

    Effects of Ginko Biloba Extract (Egb 761) on Alzheimer's Disease
    Yves Christen, Marie-Thérèse Droy-LeFaix, Catherine Pasquier, and Lester Packer
    Glutathione and Metallothionein in Oxidative Stress of Parkinson's Disease
    Manuchair Ebadi and Midori Hiramatsu
    Estrogens and Other Antioxidants in Neuroprotection: Implications for Alzheimer's Disease
    Christian Behl and Bernd Moosmann
    Therapeutic Potential of Radical Scavengers in Parkinson's Disease
    Silvia Mandel, Edna Grünblatt, and M. B. H. Youdim
    Vitamin E and Other Antioxidant Treatments for the Neurobehavioral Aspects of Alzheimer's Disease and Other Neurodegenerative Disorders
    Fadi Massoud, Mario Schittini, and Mary Sano
    Nitric Oxide and the NMDA Receptor in Ischemia and Reperfusion Injury: Is NO Protective or Injurious?
    Michael Graham Espey, Katrina M. Miranda, Carol A. Colton, Ryszard M. Pluta, Sandra J. Hewett, and David A. Wink
    Endogenous Protection of Retinal Photoreceptors Against Light-Induced Oxidative Stress
    Pier Lorenzo Marchiafava and Biancamaria Longoni

    Editorial Reviews

    "…up-to-date and comprehensive….an excellent reference for clinicians and scientists in the field of neuroscience.
    "-Saudi Medical Journal