Solid-Phase Extraction

Home
Engineering - Chemical
Chemical Processing & Design
Solid-Phase Extraction: Principles, Techniques, and Applications

Solid-Phase Extraction: Principles, Techniques, and Applications

Published:

March 15, 2000 by CRC Press - 528 Pages

Author(s):

Nigel J.K. Simpson, Varian Associates, Inc., Harbor City, California

Request
Evaluation Copy

Purchasing Options

Hardback

$167.95

ISBN 9780824700218

Cat# DK5599

eBook

Purchase >

ISBN 9781420056242

Cat# DKE5599

Features

Covers digital chromatography, the basic elements of SPE, capacity and selectivity, and the mechanisms of adsorption and desorption

Discusses nonpolar, polar, and ion-exchange extraction mechanisms, as well as complexation, chelation, and covalent retention

Explains actual vs. ideal performance and predictive SPE, as well as expert systems

Reviews using and eliminating secondary interactions and mixed-mode SPE

Delineates preparing and handling biological fluids, particulates, solid and air samples by SPE, including problem components in a sample matrix

Elucidates how to create affinity sorbents and the properties and uses of affinity SPE

Includes coverage of automation approaches, techniques for automated method development, off-line solid extraction, and on-line SPE

Explores complementary use of SPE and supercritical fluid extraction

Summary

Demonstrating the relationship of the basic theory of solid-phase extraction (SPE) to chromatography, this comprehensive reference illustrates how SPE techniques significantly contribute to the preparation of samples for a wide variety of analytical techniques. It provides step-by-step details on the applications of SPE to environmental matrices, broad-spectrum drug screening, veterinary drug abuse, pharmaceutical drug development, biological samples, and high-throughput screening. Written by world-renowned experts in the field, the book contains helpful reference charts, tables of solvent properties, selectivities, molecular acid/base properties, and more.

Introduction to Solid-Phase Extraction, N.J.K. Simpson and M.J.M. Wells
SPE Sorbents and Formats, J.J. Pesek and M.T. Matyska
The Sample Matrix and Its Influence on Method Development, N.J. K. Simpson and P.M. Wynne
Handling Large Volume Samples: Applications of SPE to Environmental Matrices, M.J.M. Wells
SPE Technology 150; Principles and Practical Consequences, M. Henry
Theory Meets Practice, C.F. Poole and S.K. Poole
Secondary Interactions and Mixed-mode Extraction, B. Law
Solid-Phase Extraction for Broad-Spectrum Drug Screening in Toxicological Analysis, R.A. de Zeeuw
The Application of SPE to Veterinary Drug Abuse, P.M. Wynne
Solid Phase Extraction of Biological Samples, S.H. Ingwersen
Solid Phase Extraction Mediated by Covalent Bonding: Applications of Immobilized Phenylboronic Acid, I. D. Wilson and P. Martin
Immuno-Affinity Extraction, D. Stevenson, B.A.A. Rashid, and S.J. Shahtaheri
Matrix Solid Phase Dispersion (MSPD), S.A. Barker
Automation of Solid Phase Extraction, L. Dordan
Integration of SPE with the Analytical Technique, Part I - Liquid Chromatography, N.J.K. Simpson
Integration of SPE with the Analytical Technique, Part II, N.J.K. Simpson
Concluding Thoughts - New Directions for SPE, N.J. K. Simpson

Appendix 1: A Summary of Common Matrix Properties and Components, N.J.K. Simpson
Appendix 2: A Comparison Between Solid Phase Extraction and Other Sample Processing Techniques, N.J.K. Simpson
Appendix 3: Ion Exchange Extraction, N.J.K. Simpson
Appendix 4: A Summary of Current Suppliers of SPE Automation Equipment, N.J.K. Simpson