Handbook of Radiotherapy Physics: Theory and Practice

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  • Delineates the biological factors that can optimize radiation therapy and the equipment used in external beam radiotherapy for treatment, simulation, and verification
  • Describes the measurements required to accurately predict dose distributions, taking into account clinical beam and patient characteristics
  • Outlines treatment planning algorithms and models as well as the essential treatment planning steps
  • Explores state-of-the-art treatment techniques, such as intensity-modulated radiotherapy, stereotactic fixation, total body irradiation, total skin irradiation, tomotherapy, particle radiotherapy, breathing adapted radiotherapy, and intensity-modulated arc therapy
  • Discusses brachytherapy and targeted radionuclide therapy, including new tumor-specific pharmaceuticals
  • Covers the risks associated with radiation treatment, the regulatory framework, and practical issues, such as the design of treatment rooms
  • Summary

    From background physics and biological models to the latest imaging and treatment modalities, the Handbook of Radiotherapy Physics: Theory and Practice covers all theoretical and practical aspects of radiotherapy physics.

    In this comprehensive reference, each part focuses on a major area of radiotherapy, beginning with an introduction by the editors and then subdividing into self-contained chapters. The first three parts present the fundamentals of the underlying physics, radiobiology, and technology involved. The ensuing sections discuss the support requirements of external beam radiotherapy, such as dose measurements, properties of clinical beams, patient dose computation, treatment planning, and quality assurance, followed by a part that explores exciting new advances that include developments in photon and particle therapy. Subsequent sections examine brachytherapy using sealed and unsealed sources and provide the framework of radiation protection, including an appendix that describes the detailed application of UK legislation. The final part contains handy tables of both physical constants and attenuation data.

    To achieve safe and effective radiotherapy, there needs to be a close understanding among various disciplines. With contributions from renowned specialists, the Handbook of Radiotherapy Physics: Theory and Practice provides essential theoretical and practical knowledge for medical physicists, researchers, radiation oncologists, and radiation technologists.

    Table of Contents


    Structure of Matter
    Interaction of Charged Particles with Matter
    Interactions of Photons with Matter
    The Monte Carlo Simulation of Radiation Transport
    Principles and Basic Concepts in Radiation Dosimetry

    Radiobiology of Tumors
    Radiobiology of Normal Tissues
    Dose Fractionation in Radiotherapy

    Kilovoltage X-Ray Units
    Linear Accelerators
    Cobalt Machines
    Portal Imaging Devices

    Ionisation Chambers
    Radiothermoluminescent Dosimeters and Diodes
    Radiation Sensitive Films and Gels
    Absolute Dose Determination under Reference Conditions
    Relative Dose Measurements and Commissioning

    From Measurements to Calculations
    Kilovoltage X-Rays
    Megavoltage Photon Beams
    Manual Dose Calculations in Photon Beams
    Electron Beams

    Principles of Patient Dose Computation
    Patient Dose Computation for Photon Beams
    Patient Dose Computation for Electron Beams
    Monte-Carlo Based Patient Dose Computation

    Target Definition
    Patient Data Acquisition
    Magnetic Resonance (MR) Imaging in Treatment Planning
    Beam Definition - Virtual Simulation
    Photon-Beam Treatment Planning Techniques
    Electron-Beam Treatment Planning Techniques
    Dose Evaluation of Treatment Plans
    Biological Evaluation of Treatment Plans

    Rationale and Management of the Quality System
    Quality Control of Megavoltage Equipment
    Quality Assurance of the Treatment Planning Process
    Quality Control of Treatment Delivery
    Recording and Verification - Networking
    Data Communication with DICOM

    Conformal and Intensity-Modulated Radiation Therapy
    Intensity-Modulation Therapy: Practical Aspects
    Stereotactic Techniques
    Proton Beams in Radiotherapy
    Total Body Irradiation (TBI)
    Total Skin Electron Irradiation
    High LET Modalities

    Clinical Introduction to Brachytherapy
    Calibration and Quality Assurance of Brachytherapy Sources
    Afterloading Equipment for Brachytherapy
    Dose Calculation for Brachytherapy Sources
    Brachytherapy Treatment Planning
    Radiobiology of Brachytherapy

    Dosimetry of Unsealed Sources
    Radionuclide Selection for Unsealed Source Therapy
    Radiopharmaceutical Targeting for Unsealed Source Therapy

    Theoretical Background to Radiation Protection
    Radiation Protection Regulation
    Practical Radiation Protection in Radiotherapy
    Radiation Protection Regulation in the United Kingdom

    Editorial Reviews

    "… Due to the broad range of topics covered and the clear, concise explanations, this text would be ideal for anyone wishing to study or refresh their knowledge of any central area of radiotherapy physics. IPEM Part 1 trainees in the UK (and any other trainee following a similar training programme elsewhere) in particular should take note … . Part 2 trainees will also benefit, especially in exploring the excellent source of referenced material. In comparison to other reference texts, the Handbook of Radiotherapy Physics is clear and also filled with many knowledgeable and useful observations and notes. … It is an excellent reference text and sits nicely on the shelf alongside your old copy of Williams and Thwaites."
    SCOPE, December 2009

    "… comprehensive reference … With contributions from renowned specialists, this book provides essential theoretical and practical knowledge to deliver safe and effective radiotherapy."
    Anticancer Research, 2009, Vol. 29

    "The editors have managed with great success to assemble the information submitted by the contributing authors and put it in a format that is concise, easy to read, and rich in content … it can serve as an excellent reference manual and resource."
    —Niko Papanikolaou, University of Texas Health Sciences Center, Medical Physics, September 2008, Vol. 35, No. 9