The Physical Measurement of Bone
Summary
Bone is a complex biological material that consists of both an inorganic and organic phase, which undergoes continuous dynamic biological processes within the body. This complex structure and the need to acquire accurate data have resulted in a wide variety of methods applied in the physical analysis of bone in vivo and in vitro. Each method has its own strengths and applications depending on the information sought by the clinician or researcher.
The Physical Measurement of Bone provides a detailed description of all the major methods of bone analysis, including brief comments on clinical evaluation. The physics of each method are introduced as well as a summary of practical procedures. The book is essential reading for practicing medical physicists and technicians who need to know about the many methods of bone analysis open to them, and, more importantly, the wide coverage provides a good introductory framework for students of medical physics and biomedical engineering.
Table of Contents
INTRODUCTION
Preface
Anatomy, Physiology and Disease
Biological Safety Considerations
Radiation Safety Considerations
Instrument Evaluation
INVASIVE TECHNIQUES
Mechanical Testing
Histomorphometry
Microscopy
IONIZING RADIATION TECHNIQUES
Photon Absorptiometry
Quantitative Computed Tomography
pQCT and mCT
Radiogrammetry
Magnetic Resonance Imaging
NONIONIZING TECHNIQUES
Quantitative Ultrasound
Finite Element Modeling
Vibration Analysis
Neutron Activation
Human Studies
Animal Studies
Editorial Reviews
"A book of this nature is long overdue as could be expected from the pedigree of the editors. The coverage is comprehensive and, thanks to the authors selected, is of high quality. The book is divided into five sections, the central three of which are concerned with the measurement techniques themselves … The invasive techniques of mechanical testing and bone histology are dealt with in great detail at a level suitable for postgraduate students looking for an introduction to these techniques at a practical level … this is an excellent and encyclopedic book which any individual or department concerned with bone measurement, or wishing to extend their knowledge of the field, should have on their bookshelf."
-J.H. Truscott, Phys. Med. Biol. 49 (May 2004), 1833
"I was impressed that there was enough known about bone measurement to fill over 600 pages. The book is short on history but strong on physical measurement of bone … The book has 18 chapters in 4 sections with a total of 22 authors. Chapter 1 is on anatomy, physiology, and diseases of bone (with a heavy emphasis on osteoporosis). Chapter 2 on biological safety is twice as long as Chapter 3 on radiation safety. It was a pleasure to read a chapter on radiation safety without seeing any mention of risk …
The book describes in detail the following physical techniques to study bone in vivo: absorptiometry with radionuclide and x-ray sources, computed tomography (quantitative-QCT and peripheral-pQCT), radiogrammetry and in vivo activation analysis, magnetic resonance imaging, quantitative ultrasound, and vibration analysis. In vitro techniques include a description of (mu)CT of bone specimens, which show the beautiful detail of trabecular bone from a tabletop instrument. Many chapters have over 100 references … For practical purposes the text has no competition.
This book is a very thorough coverage of measurement of bones … If you are doing research involving any measurement of bone it will be a valuable reference."
-J. Cameron, Med. Phys. 31(6), June 2004
