Principles of Organic Synthesis, 3rd Edition

Published:
September 16, 1993 by CRC Press - 828 Pages
Author(s):
Richard O.C. Norman; James M. Coxon, University of Canterbury, Christchurch, New Zealand
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$72.95
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ISBN 9780748761623
Cat# NT1154
 

Features

  • Shows how mechanistic principles can be applied to both acquiring a knowledge of organic synthetic processes and to planning the construction of organic compounds
  • Covers stereochemical control of reactions, reflecting the need to synthesize efficiently compounds with several asymmetric centers
  • Discusses the exploitation of lithium diisopropylamide (LDA) as a base in the formation of new C-C bonds
  • Includes coverage of free-radical reactions for the synthesis of C-C bonds and used of organosilicon compounds, and more

    • Summary

    This book is designed for those who have had no more than a brief introduction to organic chemistry and who require a broad understanding of the subject. The book is in two parts. In Part I, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions: chemical thermodynamics, structural theory, theories of reaction kinetics, mechanism itself and stereochemistry. In Part II these principles and concepts are applied to the formation of particular types of bonds, groupings, and compounds. The final chapter in Part II describes the planning and detailed execution of the multi-step syntheses of several complex, naturally occurring compounds.

    Table of Contents

    Chemical Thermodynamics. Molecular Structure. Chemical Kinetics. Mechanism. Stereochemistry. Formation of Carbon-carbon Bonds. Formation of Aliphatic Carbon-carbon Bonds. Pericyclic Reactions. Formation of Aliphatic Carbon-nitrogen Bonds. Electrophilic Aromatic Substitution. Nucleophilic Aromatic Substitution. Aromatic Diazonium Salts. Molecular Rearrangements. Reagents Containing Phosphorus, Sulfur, Silicon or Boron. Photochemical Reactions. Free-radical Reactions. Organotransition and Reagents. Oxidation. Reduction. The Synthesis of Five- and Six-Membered Heterocyclic Compounds. The Syntheses of Some Naturally Ocurring Compounds. Index.

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