Features Presents cutting-edge information about the presence and function of naturally-occurring marijuana-like substances in the human body and brain Takes a look at the fundamental role cannabinoid receptors play in human biology Addresses novel research on diseases and disorders across a number of systems Explores the development of an entirely new area of pharmaceuticals
Summary Over the past decade, there have been major advances in understanding the mechanisms whereby marijuana interacts with the brain in producing psychoactive and potentially therapeutic effects. The discovery of specific gene coding for cannabinoid receptors activated by smoking marijuana, and the finding of endogenous cannabinoids, which also activate the receptors, have transformed cannabinoid research into mainstream science with significant implications in human health and disease Endocannabinoids: The Brain and Body’s Marijuana and Beyond documentsadvances in the discovery and functioning of naturally occurring marijuana-like substances in human biology. It explores recent findings that point to the existence of an endocannabinoid physiological control system (EPCS) that directly impacts human development, health, and disease. While cannabinoid effects on the brain have received the greatest attention throughout the literature, this work looks at research on the endogenous cannabinoid system’s association across all of human physiology, including the immune, endocrine, and reproductive systems. With thoroughly researched and exceptionally insightful contributions from more than three-dozen top-flight researchers representing a cross-section of disciplines from molecular biology, genetics, and neurology to gynecology, physiology, and pharmacology, this work explores a range of topics as wide as the human body is complex. These topics include the EPCS’s relation to cell development and regulation, CNS function, immune function modulation, reproduction, and digestion, as well as its function in mental illness, neurodegenerative diseases, and cancer. The final section in the book considers the significance of endogenous cannabinoids found in some of the simplest multicellular organisms in the animal kingdom, as well as in mammalian cells at the earliest stages of development, all of which suggests that they play a fundamental role in human biology. Enocannabinoids: The Brain and Body’s Marijuana and Beyond explores areas that few books have ventured into, providing cutting-edge information that will ultimately help us better understand human biology at the systemic and perhaps even cellular level, as well as lead to the development of a whole new range of medications.
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Historical Aspects and Chemistry Look Back in Ananda—Years of Research on Cannabinoids: R Mechoulam The Relationship between Endocannabinoid Conformation and Endocannabinoid Interaction at the Cannabinoid Receptors: Patricia H Reggio Cannabinoid Receptor Genetics and Signal Transduction Endocannabinoid Receptor Genetics and Marijuana Use: Emmanuel S Onaivi, Hiroki Ishiguro, Ping Wu Zhang, Zhicheng Lin, Babatunde E Akinshola, Claire M Leonard, Sanika S Chirwa, Jianping Gong and George R Uhl Endocannabinoids and Intracellular Signaling: Sean D McAllister and Mary E Abood Endocannabinoids as Retrograde Messengers in Synaptic Transmission: Saori Oka, Yoshio Ishima, Keizo Waku, and Takayuki Sugiura Non-CB1, Non-CB2 Receptors for Endocannabinoids: Vincenzo Di Marzo and Luciano De Petrocellis Biochemistry of the Endocannabinoid System Occurrence, Biosynthesis, and Metabolism of Endocannabinoids: Takayuki Sugiura, Saori Oka, Shinobu Ikeda, and Keizo Waku Endocannabinoids and Eicosanoids: All in the Family: Sumner Burstein Endocannabinoids in CNS Physiology Synthetic Marijuana: Endocannabinoid Modulation of SynapticTransmission and Implications for the Regulation of Synaptic Plasticity: Alexander F Hoffman and Carl R Lupica Cannabinoids and the Central Serotonergic System: Marisela Morales Endocannabinoids and Dopamine-Related Functions in the CNS: Javier Fernández-Ruiz, Rosario de Miguel, Mariluz Hernández, Maribel Cebeira, and José A Ramos Pharmacology of the Oxidative Metabolites of Endocannabinoids: Ruth A Ross Behavioral Effects of Endocannabinoids :Marie-Hélène Thiébot, Frédérique Chaperon, Ester Fride, and Emmanuel S Onaivi Endocannabinoids in CNS Pathology Neuroprotection: Glutamate and Endocannabinoids : Harald S Hansen, Gitte Petersen, and Henrik H Hansen Neuropsychiatry: Schizophrenia, Depression, and Anxiety: Ester Fride and Ethan Russo The Role of Endocannabinoids in the Development, Progression, and Treatment of Neurodegenerative Diseases: Michelle Glass Endocannabinoids in Peripheral Organ Systems Endocannabinoids and Gastrointestinal Function: Nissar A Darmani Endocannabinoids and the Cardiovascular System: Michael D Randall Endocannabinoids in Inflammation and Immune Response: Evgeny V Berdyshev Involvement of the Endocannabinoid System in Cancer: Mauro Maccarrone Endocannabinoids and Endocrine Function: Laura L Murphy Endocannabinoids in Fertilization, Pregnancy, and Development: Herbert Schuel and Lani J Burkman Endocannabinoid Phylogenetics Distribution of Endocannabinoids and Their Receptors and Enzymes on the Tree of Life Endocannabinoid-Based Molecules as Potential Therapeutic Drugs: Alessia Ligresti and Vincenzo Di Marzo Index
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Editorial Reviews
“…many of the various contributors to this volume suggest that cannabinoid compounds might be useful in a variety of basal ganglia disorders, such as Parkinson’s disease, multiple sclerosis, and Alzheimer’s disease. There is even more effects in patients with Tourette’s syndrome. … All of the 36 contributors to the 23 chapters are biochemists and pharmacologists … skim the biochemistry formulae and diagrams and get to the material that will be most interesting to you … ” — Richard Evenson, in PsicCrtiques, Vol. 52, No. 12, March 2007
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