Textbook of Drug Design and Discovery, Third Edition

Textbook of Drug Design and Discovery, Third Edition

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$85.95
ISBN 9780415282888
Cat# TF1488
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eBook
ISBN 9780203301371
Cat# TFE437
 

Features

  • Includes contributions from many of the world's leading experts in medicinal chemistry and pharmaceutical research
  • Contains detailed, color illustrations of molecular models
  • Serves as a comprehensive textbook for students from undergraduate to masters level and beyond
  • Summary

    Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine.

    The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

    Table of Contents

    DRUG DESIGN AND DISCOVERY: AN OVERVIEW
    Lester A. Mitscher
    Introduction
    Historical Perspective
    What Kinds of Compounds Become Drugs?
    Preparation and Organization for Drug Seeking
    Sources of Hits, Leads, and Candidate Drugs
    Lead Optimization
    Cell Biology and Genomics as a source of Drug Targets
    Future Developments

    ROLE OF MOLECULAR RECOGNITION IN DRUG DESIGN
    Peter Andrews and Michael Dooley
    Introduction
    Thermodynamic Considerations of Drug Binding
    The Physical Basis of Intermolecular interaction
    The Total Energy of Intermolecular interaction
    Estimating Individual Group Components in Ligand-Receptor Interactions and Co-
    Operativity
    Some Rules of Thumb

    STEREOCHEMISTRY IN DRUG DESIGN
    Ian J. Kennedy and David E. Jane
    Introduction
    What Are Stereoisomers?
    The Origin of Stereospecificity in Molecular Recognition
    Why is Stereochemistry Important in Drug Design?
    Methods of Obtaining Pure Stereoisomers
    Analytical Methods of Determining Purity of Stereoisomers

    COMPUTER-AIDED DEVELOPMENT OF THREE-DIMENSIONAL PHARMACOPHORE MODELS
    Tommy Liljefors and Ingrid Petterson
    Structure-and Pharmacophore-Based Ligand Design
    The Pharmacophore Concept
    Basic Principles and a Step-By-Step Procedure
    Pharmacophore Elements and Their Representations
    The Receptor-Bound or 'Active' Conformation
    Molecular Superimposition
    Receptor-Excluded and Receptor-Essential Volumes
    Solvation Effects
    Examples of 3D-Pharmacophore Models and Their Use

    QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS AND EXPERIMENTAL DESIGN
    Ulf Norinder and Thomas Hoberg
    Introduction
    Hansch Analysis
    Physico-Chemical Properties
    Applications of Hansch Equations
    Pattern Recognition
    3D-QSAR Methodologies
    Experimental Design

    RECEPTORS: STRUCTURE, FUNCTION AND PHARMACOLOGY
    Hans Brauner-Osborne
    Introduction
    Receptor Structure and Function
    Receptor Pharmacology

    Editorial Reviews

    "Describing all facets of modern drug design and development, this major textbook is an invaluable source of information for students of chemistry, phamacology, pharmacy, medicinal chemistry, medicine and biochemistry at all levels…Almost every page is illustrated with figures, tables and structural formulae."
    Unlisted Drugs

    "A well-structured and informative book…"
    S. Damment, Glaxo, Newsletter of British Society for Toxicology

    "Excellent book…The editors set a high standard."
    Professor Graham Johnston, TiPS

    "…a good and substantial book…good introductions to many aspects of a complex subject…"
    Chris Ramsden, Chemistry and Industry

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