3rd Edition

The Lymphoid Neoplasms 3ed

By Ian Magrath Copyright 2010
    1689 Pages 50 Color & 330 B/W Illustrations
    by CRC Press

    This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengthened for this third edition, to the environmental factors that may be relevant to disease development, and, finally, to the pragmatic aspects of disease management. The authors synthesise for the reader apsects of current knowledge and likely future developments, and direct them to the appropriate resources should they wish to pursue particular avenues of scientific or literature research.

    INTRODUCTION
    Introduction to the lymphoid neoplasms
    Historical perspective: the evolution of modern concepts of lymphoid neoplasia

    EPIDEMIOLOGY
    Descriptive epidemiology
    Causes and prevention of lymphoma
    Immunologic and genetic predisposition
    Epidemiology of exogenous human retroviruses associated with hematologic malignancies
    Herpesviruses and lymphoma
    Other microorganisms associated with lymphoid neoplasms

    IMMUNOBIOLOGY
    Overview of the immune system
    Ontogeny of T and natural killer cells
    Ontogeny of B cells
    Cellular immunobiology of lymph nodes and spleen
    Cellular immunobiology of extranodal lymphoid tissue
    Biology of plasma cells
    Interleukins and lymphoid neoplasia
    Lymphocyte homing and the dissemination of lymphoid malignancies
    Mouse models of human B lymphoid neoplasms

    CLASSIFICATION AND PATHOGENESIS
    Classification of lymphoid neoplasms
    Borderlands between pathological entities: composite lymphomas
    Chromosomal and molecular alterations in lymphoid malignancies: basic principles and detection methods
    Molecular basis of chromosomal translocations
    Genesis and consequences of genetic lesions in lymphoma classification
    Gene expression patterns in lymphoma classification
    Immunodeficieny, inherited and acquired, and lymphomagenesis
    Chronic inflammation, including autoimmunity, and lymphogenesis

    PATHOLOGY AND PATHOGENESIS OF SPECIFIC LYMPHOMAS
    Lymphoblastic lymphomas and leukemias
    Chronic lymphoid leukemias and u heavy chain disease
    Hairy cell leukemia
    Mantle cell lymphoma
    Marginal zone lymphomas
    Follicular lymphoma
    Burkitt lymphoma
    Diffuse large B cell lymphomas
    Hodgkin lymphoma
    Plasma cell neoplasms
    Natural killer (NK) cell neoplasms
    Anaplastic large cell lymphoma
    Mycosis fungoides and Sezary Syndrome: pathophysiology and pathology
    Other peripheral T cell lymphomas: pathology and molecular pathogenesis

    PRESENTING FEATURES, DIAGNOSIS AND STAGING
    Presenting features of lymphoid neoplasms
    The art of histological diagnosis
    Immunophenotyping as a diagnostic and prognostic tool
    The utility of molecular genetic studies in the diagnosis, prognostic assessment and monitoring of lymphoid malignancies
    Radiologic, ultrasound and magnetic resonance imaging
    Radionuclide imaging
    Staging systems and staging investigations at presentation
    Special aspects of diagnosis in developing countries
    Imaging lymphomas in developing countries

    GENERAL PRINCIPLES OF MANAGEMENT
    Emergency management in lymphoid malignancies
    Systemic therapy of lymphoma
    Role of radiation therapy
    Response assessment and follow-up of the patient with malignant lymphoma
    Prognostic factors and risk adaptation
    Second-line therapy for lymphoid neoplasms
    High-dose therapy with stem cell rescue
    Management of lymphoid neoplasia during pregnancy
    Management of lymphoid malignancies in the infant
    Management of lymphoid neoplasms in the elderly
    Management of lymphomas at extranodal locations
    Special aspects of management of lymphomas in developing countries
    Late effects of cancer treatment and quality of life

    MANAGEMENT OF SPECIFIC DISEASES
    Lymphoblastic lymphoma and leukemia in children
    Acute lymphoblastic leukemia and lymphoma in adults
    Small B cell lymphomas and leukemias with hairy cell leukemia
    Mantle cell lymphoma
    Marginal zone lymphomas
    Follicular lymphoma
    Burkitt lymphoma/leukemia in children
    Burkitt and Burkitt like lymphoma/leukemia in adults
    Diffuse large B cell lymphoma in children
    Diffuse large B cell lymphomas in adults
    Hodgkin lymphoma in adults
    Hodgkin lymphoma in children
    Plasma cell neoplasms
    The management of natural killer cell malignancies
    Anaplastic large cell lymphoma in adults
    Anaplastic large cell lymphoma in children
    Mycosis fungoides and Sezary Syndrome
    Adult T-cell leukemia/lymphoma
    Other peripheral T cell lymphomas
    HIV-associated lymphoid neoplasms
    Lymphoid neoplasms in immunodeficiency, immunosuppression, and autoimmunity
    Uncommon histologic subtypes of non-Hodgkin lymphoma in children

    FUTURE DIRECTIONS IN DIAGNOSIS AND TREATMENT
    Molecular profiling and lymphoma diagnosis
    New therapies for lymphoid neoplasms
    Monoclonal antibody therapy for lymphomas and leukemias
    Cellular therapies for lymphoma
    Vaccine therapies
    Lymphoma microenvironment
    Molecular pathway therapy for non-Hodgkin lymphomas
    Therapeutic strategies employing viral-associated targets

    Biography

    Ian T. Magrath DSc (Med), FRCP, FRCPath
    President, International Network for Cancer Treatment and Research,
    Adjunct Professor of Pediatrics, Uniformed Services University of the Health Sciences,
    International Network for Cancer Treatment and Research,
    Brussels, Belgium

    Section editors:

    Kishor Bhatia PhD, FRCPath
    Director, AIDS Malignancy Program
    OHAM, NCI, NIH
    Bethesda, MD
    USA

    Paolo Boffetta MD, MPH
    Head of Environment Section, IARC
    Lifestyle and Cancer Group
    International Agency for Research on Cancer
    Lyon
    France

    Claire Dearden BSc, MD, FRCP, FRCPath
    Consultant Haematologist
    Department of Haemato-Oncology
    Royal Marsden NHS Foundation Trust and Institute of Cancer Research
    London
    UK

    Volker Diehl MD, PhD
    Professor of Internal Medicine, Hematology and Oncology
    Honorary Chairman of German Hodgkin Study Group (GHSG)
    Former Head of Department I of Internal Medicine
    University Hospital Cologne
    Cologne
    Germany

    Randy D. Gascoyne MD, FRCPC
    Clinical Professor of Pathology
    Department of Pathology and Laboratory Medicine
    British Columbia Cancer Agency and
    The University of British Columbia
    Research Director, Centre for Lymphoid Cancers
    Senior Scientist, BC Cancer Research Centre
    Vancouver, BC
    Canada

    Hans Konrad Müller-Hermelink Prof. Dr. Dr. h. c.
    Professor and Chairman
    Institute of Pathology
    University of Würzburg
    Würzburg
    Germany

    Michael Potter MD
    Scientist, Emeritus
    Laboratory of Cell Biology and Genetics
    National Cancer Institute, NIH
    Bethesda, MD
    USA

    Ama Z. S. Rohatiner MD, FRCP
    Professor of Haemato-Oncology
    Department of Medical Oncology,
    St. Bartholomew's Hospital
    London
    UK