Cell Biology

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Protocols for Cytogenetic Mapping of Arthropod Genomes

Protocols for Cytogenetic Mapping of Arthropod Genomes

Igor V. Sharakhov

October 28, 2014

Arthropods are important to worldwide agriculture, food safety, human health, and energy production. Besides their practical significance, various species represent excellent model systems for biological investigations of evolution, development, physiology, reproduction, and social interaction. For...

Cell Membrane Nanodomains: From Biochemistry to Nanoscopy

Cell Membrane Nanodomains: From Biochemistry to Nanoscopy

Alessandra Cambi, Diane S. Lidke

October 27, 2014

Cell Membrane Nanodomains: From Biochemistry to Nanoscopy describes recent advances in our understanding of membrane organization, with a particular focus on the cutting-edge imaging techniques that are making these new discoveries possible. With contributions from pioneers in the field, the book...

Protein Transport into the Endoplasmic Reticulum

Protein Transport into the Endoplasmic Reticulum

Richard Zimmermann

September 13, 2014

Protein transport into the endoplasmic reticulum (ER) is just one aspect of the general cell biology topic of intracellular protein sorting. This larger picture also includes protein transport into other organelles of the eukaryotic cell (chloroplasts, mitochondria, nucleus, peroxisomes), protein...

Cellular In Vitro Testing: Methods and Protocols

Cellular In Vitro Testing: Methods and Protocols

John Haycock, Arti Ahluwalia, J. Malcolm Wilkinson

August 27, 2014

Growing cells in 2D under static conditions has long been the gold standard of cell culture, despite this method not being representative of the complex in vivo environment. The use of animal models also has clear ethical and scientific limitations, and increasingly the 3Rs (replacement, refinement...

Liver Metabolism and Fatty Liver Disease

Liver Metabolism and Fatty Liver Disease

Oren Tirosh

August 27, 2014

Nonalcoholic fatty liver disease is one of the most common liver diseases worldwide affecting patients from all ages, races, and ethnic backgrounds. It comprises a spectrum of hepatic pathology ranging from simple steatosis, in which there is an increase of fat accumulation in hepatocytes, to...

Vascularization: Regenerative Medicine and Tissue Engineering

Vascularization: Regenerative Medicine and Tissue Engineering

Eric M. Brey

August 07, 2014

A Complex and Growing Field The study of vascularization in tissue engineering and regenerative medicine (TERM) and its applications is an emerging field that could revolutionize medical approaches for organ and tissue replacement, reconstruction, and regeneration. Designed specifically for...

Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer

Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer

Kasirajan Ayyanathan

June 20, 2014

Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing...

Cell Signaling

Cell Signaling

Wendell Lim, Bruce Mayer, Tony Pawson

June 16, 2014

Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the conceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate.  By emphasizing the common design...

Stem Cells: From Basic Research to Therapy, Volume Two: Tissue Homeostasis and Regeneration during Adulthood, Applications, Legislation and Ethics

Stem Cells: From Basic Research to Therapy, Volume Two: Tissue Homeostasis and Regeneration during Adulthood, Applications, Legislation and Ethics

Federico Calegari, Claudia Waskow

June 03, 2014

The second volume in the Stem Cells series concentrates on the mechanisms of stem cell regeneration in the adult organism with a view towards understanding how lost tissue can be replaced during adulthood and aging. The second focus of this volume is on stem cell identification and manipulation,...

Hormesis in Health and Disease

Hormesis in Health and Disease

Suresh I. S. Rattan, Éric Le Bourg

May 16, 2014

Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the...

Atomic Force Microscopy in Nanobiology

Atomic Force Microscopy in Nanobiology

Kunio Takeyasu

May 12, 2014

Recent developments in atomic force microscopy (AFM) have been accomplished through various technical and instrumental innovations, including high-resolution and recognition imaging technology under physiological conditions, fast-scanning AFM, and general methods for cantilever modification and...

Extracellular Vesicles in Health and Disease

Extracellular Vesicles in Health and Disease

Paul Harrison, Chris Gardiner, Ian L. Sargent

May 02, 2014

Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of...